A Review of Magnetic Nanoparticle-Based Surface-Enhanced Raman Scattering Substrates for Bioanalysis: Morphology,...

Area of Science:

• Analytical Chemistry
• Nanotechnology
• Biotechnology

Background:

• Surface-Enhanced Raman Scattering (SERS) is a sensitive, non-destructive analytical technique for biotarget detection.
• Magnetic nanoparticles (MNPs) are increasingly used to create advanced SERS substrates for bioanalysis.
• Research on magnetic SERS substrates has surged in the past decade, focusing on analytical applications.

Purpose of the Study:

• To review recent advancements in magnetic nanoparticle-based SERS substrates for bioanalysis.
• To categorize these substrates by morphology (core-shell, core-satellite, non-spherical) and function (separation, enrichment, recognition, SERS tags).
• To summarize applications in detecting amino acids, proteins, nucleic acids, and cancer biomarkers.

Main Methods:

• Systematic review of recent literature on magnetic nanoparticle-SERS substrates.
• Analysis of substrate morphologies and their roles in bioassays.
• Summary of application data for various biomolecules and disease markers.

Main Results:

• Magnetic SERS substrates exhibit improved selectivity and accuracy in bioassays.
• Diverse morphologies (core-shell, core-satellite, non-spherical) offer tailored functionalities.
• Successful applications demonstrated for detecting a wide range of biological targets.

Conclusions:

• Magnetic nanoparticle-based SERS substrates represent a powerful tool for sensitive and specific bioanalysis.
• Future trends point towards further optimization of substrate design and expanded applications in diagnostics.
• This review provides valuable insights for researchers in SERS bioanalysis.