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Related Concept Videos

Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...

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Related Experiment Video

Updated: Jul 4, 2026

Dissection and Culture of Commissural Neurons from Embryonic Spinal Cord
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Establishing Hedgehog Gradients during Neural Development.

Sara Douceau1,2, Tanya Deutsch Guerrero1,2, Julien Ferent1,2

  • 1INSERM UMR-S 1270, F-75005 Paris, France.

Cells
|January 21, 2023
PubMed
Summary

Sonic Hedgehog (Shh) forms crucial gradients in embryonic development. This review explores Shh sources, distribution mechanisms, and how disruptions cause disorders and cancers, revisiting classical models with new techniques.

Keywords:
Sonic Hedgehoggradientmorphogenneurodevelopment

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Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Neuroscience

Background:

  • Morphogen gradients are fundamental to embryonic development.
  • Sonic Hedgehog (Shh) is a key morphogen involved in neuronal patterning and axon guidance.
  • Understanding Shh gradient formation and maintenance is critical but remains an active research area.

Purpose of the Study:

  • To review the diverse sources of Shh in nervous system development.
  • To detail the mechanisms by which Shh distributes in tissues.
  • To examine the consequences of disrupted Shh gradients in disease.

Main Methods:

  • Literature review of Shh function in embryonic development.
  • Analysis of cellular and molecular mechanisms of Shh distribution.
  • Discussion of neurodevelopmental disorders and cancers linked to Shh signaling.

Main Results:

  • Identified multiple Shh sources in the developing nervous system.
  • Described various mechanisms for Shh gradient formation and maintenance.
  • Highlighted the link between Shh dysregulation and severe pathologies.

Conclusions:

  • Shh gradients are essential for proper neurodevelopment.
  • Disruptions in Shh distribution lead to significant developmental defects and disease.
  • Emerging technologies like organoids offer new avenues to study classical morphogen models.