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Ventilation Induces Changes in Pulse Wave Transit Time in the Pulmonary Artery
Fabian Mueller-Graf1,2, Paul Frenkel1, Chiara Felicitas Albus1
1Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Medical Center Rostock, Schillingallee 35, 18057 Rostock, Germany.
Biomedicines
|January 21, 2023
Summary
Ventilation causes periodic changes in pulse wave transit time (PWTT) and pulmonary artery pressure (PAP). These changes are not synchronous, creating a hysteresis loop, suggesting the respiratory cycle impacts PWTT as a PAP surrogate.
Area of Science:
- Physiology
- Cardiovascular Research
- Respiratory Mechanics
Background:
- Pulse wave transit time (PWTT) is a potential non-invasive surrogate for pulmonary artery pressure (PAP).
- Understanding ventilation's impact on PWTT is crucial for its clinical application.
Purpose of the Study:
- To investigate ventilation-induced periodic changes in PWTT.
- To explore the mechanisms behind these changes and their relationship with PAP.
Main Methods:
- Measurements of PWTT and mean PAP in five healthy pigs using pulmonary artery catheters.
- Application of pressure-controlled mechanical ventilation.
- Analysis of ventilation-dependent changes and their synchronicity.
Main Results:
- Ventilation induced synchronous changes in PWTT and mean PAP, but with a notable hysteresis.
- Inspiration led to a rapid decrease in PWTT as PAP plateaued.
- Expiration showed a rapid increase in PWTT as PAP reached its minimum.
- Hysteresis disappeared during apnea.
Conclusions:
- Ventilation-induced changes in PWTT are non-synchronous with PAP changes, exhibiting a characteristic hysteresis.
- Inspiration significantly shortens PWTT.
- The respiratory cycle must be considered when utilizing PWTT as a surrogate for PAP.
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