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Related Experiment Video

Updated: Jul 1, 2026

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans

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Published on: December 18, 2016

Subcortical Structures in Demented Schizophrenia Patients: A Comparative Study.

Juan Rivas^1,2,3,4, Santiago Gutierrez-Gomez^5,6, Juliana Villanueva-Congote⁷

¹Department of Psychiatry, Fundación Valle del Lili Cra. 98 # 18-49, Cali 760032, Colombia.

|January 21, 2023

Summary

Older schizophrenia patients with dementia show significant cognitive decline and brain structure differences, particularly in the hippocampus, amygdala, and thalamus, compared to those without dementia and healthy controls.

Keywords:

aged amygdala dementia hippocampus neuropsychological tests schizophrenia thalamus

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Last Updated: Jul 1, 2026

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Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

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Published on: September 8, 2021

Area of Science:

Neuroscience
Geriatrics
Psychiatry

Background:

Few studies explore structural brain differences in older patients with schizophrenia and dementia.
Cognitive decline is a significant concern in aging populations with schizophrenia.

Purpose of the Study:

To investigate the relationship between cognitive performance and brain volumes in older schizophrenia patients.
To identify structural brain differences associated with dementia in schizophrenia.

Main Methods:

Compared cognitive performance using neuropsychological tests in three groups: schizophrenia with dementia (SD), schizophrenia without dementia (SND), and healthy controls (CG).
Measured brain volumes using magnetic resonance imaging (MRI).
Analyzed differences in cognitive domains and specific brain regions (hippocampus, amygdala, thalamus).

Main Results:

Cognitive performance was significantly better in CG than in schizophrenic patients.
SD patients performed worse than SND patients, except in semantic memory and visual attention.
Significant differences in hippocampal, amygdala, and thalamic volumes were observed, particularly between SD and CG, and between SD and SND.

Conclusions:

Cognitive function and structural brain changes can differentiate schizophrenia patients from healthy controls, with more pronounced alterations in those with dementia.
Volume loss in the hippocampus, amygdala, and thalamus may be linked to dementia development in schizophrenia patients.
Functional alterations in SD and SND patients often coincide but can be in opposite directions.