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Potential Involvement of LncRNAs in Cardiometabolic Diseases

Mirolyuba Ilieva1, Shizuka Uchida1

  • 1Center for RNA Medicine, Department of Clinical Medicine, Aalborg University, DK-2450 Copenhagen SV, Denmark.

Genes
|January 21, 2023
PubMed

Insights

Long non-coding RNAs (lncRNAs) are crucial for understanding cardiometabolic diseases like diabetes and cardiovascular disease. This study reviews lncRNA research, focusing on genetic factors influencing obesity, cholesterol, and hypertension.

Area of Science:

  • Genomics
  • Molecular Biology
  • Cardiovascular Research

Background:

  • Cardiometabolic diseases, including cardiovascular disease and diabetes, are leading global causes of mortality.
  • Understanding their pathogenesis is critical, yet complex.
  • Non-protein-coding RNAs (ncRNAs), particularly long ncRNAs (lncRNAs), represent a significant, under-explored area of the genome.

Purpose of the Study:

  • To summarize current trends in long non-coding RNA (lncRNA) research concerning cardiometabolism.
  • To highlight the role of lncRNAs in major cardiometabolic risk factors: obesity, cholesterol, diabetes, and hypertension.
  • To emphasize the influence of genetic factors on lncRNAs in the context of cardiometabolic diseases.

Main Methods:

  • Literature review focusing on recent lncRNA studies.
  • Analysis of lncRNA involvement in key cardiometabolic risk factors.
  • Emphasis on genetic aspects of lncRNA function in disease.

Main Results:

  • lncRNAs are increasingly recognized as key players in the pathogenesis of cardiometabolic diseases.
  • Specific lncRNAs are implicated in regulating pathways related to obesity, dyslipidemia, diabetes, and hypertension.
  • Genetic variations in lncRNAs can significantly impact an individual's susceptibility to cardiometabolic conditions.

Conclusions:

  • lncRNAs offer novel insights into the complex mechanisms underlying cardiometabolic diseases.
  • Targeting lncRNAs presents potential therapeutic strategies for managing cardiometabolic risk factors.
  • Further research into the genetic underpinnings of lncRNAs is essential for personalized medicine approaches.

Keywords:
cardiovasculargeneticslncRNAmetabolism

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