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Precision Ultrasound-guided Stem Cell Delivery for Vascular Repair in Aortic Diseases
Published on: June 20, 2025
218
Molecular and Cellular Mechanisms Involved in Aortic Wall Aneurysm Development
Iris Bararu Bojan Bararu1, Carmen Elena Pleșoianu2,3, Oana Viola Badulescu1
1Department of Pathophysiology, Morpho-Functional Sciences, Faculty of Medicine, 'Grigore T. Popa' University of Medicine and Pharmacy, 16 Unirii Street, 700115 Iași, Romania.
Diagnostics (Basel, Switzerland)
|January 21, 2023
Summary
Aortic aneurysms, a common vascular disease, can lead to fatal rupture. Current surgical treatments have risks, highlighting the need for new molecular targets to block aneurysm formation.
Area of Science:
- Vascular Biology
- Cardiovascular Medicine
- Pathogenesis Research
Background:
- Aortic aneurysms are common pathologies affecting thoracic or abdominal aorta, with distinct characteristics.
- These aneurysms can progress asymptomatically, culminating in life-threatening aortic rupture.
- Existing therapies for acute aortic syndromes are limited, making surgery the primary treatment.
Purpose of the Study:
- To review the mechanisms underlying aortic aneurysm development.
- To identify current and potential treatment strategies for aortic aneurysms.
- To explore molecular and cellular pathways involved in aneurysm pathogenesis.
Main Methods:
- Literature review of aortic aneurysm mechanisms and treatments.
- Analysis of molecular and cellular factors in aneurysm formation.
- Comparison of human tissue and animal model findings.
Main Results:
- Surgical management, while advanced, still carries significant morbidity and mortality.
- Understanding cellular and molecular networks is crucial for identifying novel therapeutic targets.
- Limited therapies exist to prevent or delay acute aortic syndromes.
Conclusions:
- Further research into molecular and cellular mechanisms is essential for developing targeted therapies.
- Comparative studies using human tissues and animal models are needed.
- Identifying pharmacological strategies to block pathogenic pathways could revolutionize aneurysm treatment.
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