Related Experiment Video
Updated: Aug 13, 2025

From a 2DE-Gel Spot to Protein Function: Lesson Learned From HS1 in Chronic Lymphocytic Leukemia
Published on: October 19, 2014
Crystal-Storing Histiocytosis: The Iceberg of More Serious Conditions
Mousa Mobarki1, Alexandra Papoudou-Bai2, Jean Marc Dumollard3
1Pathology Department, Faculty of Medicine, Jazan University, Jazan 45142, Saudi Arabia.
Abstract:
Crystal-storing histiocytosis is a rare condition that is histologically characterized by intracellular cytoplasmic crystalline inclusions. It usually presents monoclonal immunoglobulins that deposit within histiocytes, which accumulate and affect different organs of the human body and are commonly associated with lymphoproliferative conditions, especially those with plasmacytic differentiation. The prognosis of this condition is variable and related to the underlying clinical disease. In this review article, we aim to describe and discuss the clinical and pathological characteristics of crystal-storing histiocytosis based on the available literature and to provide a thorough differential diagnosis.

