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The Correlation between the Vascular Calcification Score of the Coronary Artery and the Abdominal Aorta in Patients
Trang Nguyen-Mai Huynh1, Fumikazu Yamazaki1,2, Izumi Kishimoto1
1Department of Dermatology, Kansai Medical University, Osaka 573-1010, Japan.
Insights
Psoriasis patients show moderate correlation between coronary artery calcification score (CACS) and abdominal aortic calcification score (AACS). These scores may help predict coronary lesions, independent of psoriasis severity.
Area of Science:
- Cardiology
- Dermatology
- Radiology
Background:
- Psoriasis is an independent cardiovascular disease risk factor due to chronic inflammation.
- Limited research exists on atherosclerosis progression in coronary arteries versus other major vessels in psoriasis patients.
Purpose of the Study:
- To investigate the correlation and development of coronary artery calcification score (CACS) and abdominal aortic calcification score (AACS) in psoriasis patients.
- To assess the predictive value of CACS and AACS for coronary artery lesions.
Main Methods:
- Eighty-three psoriasis patients underwent coronary computed tomography angiography (CCTA) for CACS and abdominal computed tomography (AbCT) for AACS.
- Clinical data, PASI scores, and blood samples were collected; medical histories were reviewed.
- Linear regression analysis was used to determine associations between CACS and AACS.
Main Results:
- A moderate correlation was observed between CACS and AACS.
- Both scores reflected coronary plaque and stenosis characteristics identified by CCTA.
- CACS was significantly higher in psoriatic arthritis patients, but AACS was not; neither score correlated with PASI score.
Conclusions:
- CACS and AACS demonstrate a correlation in psoriasis patients.
- Both CACS and AACS may serve as potential indicators for predicting coronary lesions identified via CCTA.
Abstract:
Psoriasis is known as an independent risk factor for cardiovascular disease due to its chronic inflammation. Studies have been conducted to evaluate the progress of atherosclerotic plaques in psoriasis. However, inadequate efforts have been made to clarify the relationship between atherosclerosis progress in coronary arteries and other important blood vessels. For that reason, we investigated the correlation and development of the coronary artery calcification score (CACS) and the abdominal aortic calcification score (AACS) during a follow-up examination. Eighty-three patients with psoriasis underwent coronary computed tomography angiography (CCTA) for total CACS and abdominal computed tomography (AbCT) for total AACS. PASI score, other clinical features, and blood samples were collected at the same time. The patients' medical histories were also retrieved for further analysis. Linear regression was used to analyze the CACS and AACS associations. There was a moderate correlation between CACS and AACS, while both calcification scores relatively reflected the coronary plaque number, coronary stenosis number, and stenosis severity observed with CCTA. Both calcification scores were independent of the PASI score. However, a significantly higher CACS was found in psoriatic arthritis, whereas no similar phenomenon was recorded for AACS. To conclude, both CACS and AACS might be potential alternative tests to predict the presence of coronary lesions as confirmed by CCTA.
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