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Related Experiment Video

Updated: Aug 13, 2025

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

Malignant Prostate Tissue Is Associated with Different Microbiome Gene Functions.

Jae Heon Kim^1,2, Hoonhee Seo^2,3, Sukyung Kim³

¹Department of Urology, Soonchunhyang University School of Medicine, Seoul 14584, Republic of Korea.

Diagnostics (Basel, Switzerland)

|January 21, 2023

Summary

Prostate cancer tissue (MT) and benign prostate hyperplasia (BPH) samples show distinct microbiome compositions and functional genes. Pelomonas was the most abundant genus in malignant prostate tissues, suggesting a role in tumorigenesis.

Keywords:

16S rRNA microbiome prostate carcinoma

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Last Updated: Aug 13, 2025

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

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Published on: September 8, 2015

Laser-capture Microdissection of Human Prostatic Epithelium for RNA Analysis

Laser-capture Microdissection of Human Prostatic Epithelium for RNA Analysis

Published on: November 26, 2015

MicroRNA Detection in Prostate Tumors by Quantitative Real-time PCR qPCR

MicroRNA Detection in Prostate Tumors by Quantitative Real-time PCR qPCR

Published on: May 16, 2012

Area of Science:

Urology
Microbiology
Oncology

Background:

Microbiome alterations are associated with human pathologies, including cancer.
The prostate microbiome's role in prostatic adenocarcinoma (cancer) development is not fully understood.

Purpose of the Study:

To compare the microbiome composition and functional genes in malignant prostate tissues (MT) versus benign prostate tissues (BT) or benign prostatic hyperplasia (BPH).
To determine the microbiome's relevance to prostate cancer development (tumourigenesis).

Main Methods:

Microbiome analysis of prostate tissue specimens.
Comparison of bacterial constituents and functional genes between malignant and benign samples.
Specimens included MT (n=26), PT (n=13), and BPH (n=10).

Main Results:

No significant microbiome variations were observed between malignant prostate tissues (MT) and prostatectomy (PT) specimens.
Distinct differences in bacterial constituents and functional genes were found when comparing MT against BPH samples.
The genus Pelomonas showed the highest abundance in MT specimens.

Conclusions:

The microbiome composition does not significantly differ between malignant prostate tissues and prostatectomy tissues.
Functional gene differences in the microbiome are present between malignant prostate tissues and benign prostatic hyperplasia.
These findings suggest that specific microbiome gene functions may be relevant in the context of prostate cancer.