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Updated: Aug 13, 2025

Spontaneous Murine Model of Anaplastic Thyroid Cancer
Published on: February 3, 2023
Delayed Presentation of Functioning Metastasis in a Patient with Follicular Thyroid Carcinoma
Maria Inês Alexandre1, Sara Donato2, Helena Vilar2
1Serviço de Endocrinologia, Diabetes e Metabolismo, Hospital de Santa Maria, Avenida Prof. Egas Moniz, 1649-028 Lisboa, Portugal.
Abstract:
Functioning metastases from differentiated thyroid carcinoma are rare and present a great therapeutic challenge. Here, we present an unusual case of a patient with metastatic thyroid carcinoma who developed a hyperthyroid state a few years after the diagnosis due to functioning metastases. Radioiodine treatment was effective in controlling the hyperthyroidism; however, it had no effect on tumor burden. By sharing our experience with this case, we hope to raise awareness for this rare condition and the ways to manage it.
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