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Prognostic Role of CD200 in Acute Lymphoblastic Leukemia Patients
Mohamed Khalil1, Nahla Elsharkawy1, Mona Mohsen Elmawardy1
1Department of Clinical and Chemical Pathology, National Cancer Institute, Cairo University, Cairo 11796, Egypt.
CD200 is highly expressed in acute lymphoblastic leukemia (ALL) patients, correlating with key diagnostic markers. This finding suggests CD200
Area of Science:
- Hematology
- Immunology
- Oncology
Background:
- CD200 overexpression is noted in acute lymphoblastic leukemia (ALL) patients.
- CD200 may aid in characterizing leukemia-initiating cells (LICs).
Purpose of the Study:
- Investigate CD200 expression patterns on leukemic B cells.
- Correlate CD200 expression with clinical and laboratory findings in ALL patients.
Main Methods:
- Included 62 newly diagnosed ALL patients.
- Performed full history, clinical examination, CBC, BM aspiration, immunophenotyping, and CD200 expression analysis.
Main Results:
- CD200 expression was significantly higher in ALL patients (66.15 ± 23.08) versus controls (0.37 ± 0.2) (p ≤ 0.001).
- CD200 expression correlated significantly with total leucocytic count and hemoglobin levels (p = 0.001, 0.03).
Conclusions:
- CD200 was expressed in 100% of ALL patients.
- CD200 expression impacts diagnostic findings and may aid in minimal residual disease detection using PRISM software.
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