Contribution of Genetic Polymorphisms in Human Health
Pieranna Chiarella1, Pasquale Capone1, Renata Sisto1
1Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, INAIL Research, Via Fontana Candida 1, Monteporzio Catone, 00078 Rome, Italy.
International Journal of Environmental Research and Public Health
|January 21, 2023
Summary
Understanding genetic factors and lifestyle choices is key to preventing chronic diseases and promoting public health. Precision medicine offers personalized approaches by considering individual genetic variability and clinical history.
Area of Science:
- Public Health
- Genetics
- Environmental Health
Background:
- Human health is shaped by a complex interplay of genetic inheritance, lifestyle, socioeconomic, and environmental factors.
- While these elements are crucial for health promotion, their precise impact on population health remains unclear.
- Environmental and occupational exposures, often poorly understood, significantly influence individual health outcomes.
Purpose of the Study:
- To investigate the role of susceptibility biomarkers, specifically genetic polymorphisms, in population health.
- To examine risk factors associated with specific exposures in European populations.
- To discuss the potential of precision medicine in disease prevention and treatment.
Main Methods:
- Review of existing literature on genetic polymorphisms and environmental exposures.
- Analysis of susceptibility biomarkers across different ethnicities, with a focus on Europeans.
- Exploration of precision medicine's application in personalized healthcare.
Main Results:
- Genetic polymorphisms (susceptibility biomarkers) play a role in individual responses to environmental and occupational exposures.
- Personal habits and lifestyle choices significantly contribute to chronic disease development and reduced life expectancy.
- Precision medicine offers a novel approach by integrating genetic variability, clinical history, and lifestyle.
Conclusions:
- Genetic variability influences health outcomes and disease risk.
- Personalized healthcare strategies, like precision medicine, are essential for effective disease prevention and treatment.
- Further research is needed to fully elucidate the complex interactions between genetic, environmental, and lifestyle factors in public health.
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