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Updated: Aug 13, 2025

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model
Published on: November 29, 2024
Comprehensive Study of a Diabetes Mellitus Mathematical Model Using Numerical Methods with Stability and Parametric
Mohammad AlShurbaji1, Lamis Abdul Kader1, Hadia Hannan1
1Biomedical Engineering Graduate Program, American University of Sharjah, Sharjah P.O. Box 26666, United Arab Emirates.
Mathematical modeling of diabetes complications helps monitor the disease
Area of Science:
- Mathematical Biology
- Public Health Modeling
- Epidemiology
Background:
- Diabetes is a global epidemic with significant public health implications.
- Effective monitoring and control strategies are crucial for managing diabetes prevalence and complications.
- Mathematical models offer a valuable tool for understanding and predicting disease progression.
Purpose of the Study:
- To analyze the diabetes complication (DC) mathematical model using various numerical methods.
- To investigate the impact of time step size and model parameters on diabetes progression.
- To provide insights for improving public health strategies for diabetes screening and treatment.
Main Methods:
- Analysis of the DC model using five distinct numerical methods.
- Examination of the influence of time step size on model convergence.
- Parametric analysis to understand the role of different parameters in diabetes complication development.
Main Results:
- The Runge-Kutta (RK) method demonstrated the highest accuracy in modeling diabetes complications.
- Adam-Moulton's method also yielded favorable results for the DC model.
- Parametric analysis highlighted the critical role of specific parameter values in model convergence.
Conclusions:
- The study offers a comprehensive understanding of diabetes complication development post-diagnosis.
- Numerical analysis of the DC model can inform public health policy and intervention strategies.
- Findings support the development of targeted initiatives for diabetes screening and treatment to improve national health outcomes.
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