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The Bidirectional Relationship between Pulmonary Tuberculosis and Lung Cancer
Mădălina Preda1,2, Bogdan Cosmin Tănase3, Daniela Luminița Zob4
1Marius Nasta Institute of Pneumology, 050159 Bucharest, Romania.
International Journal of Environmental Research and Public Health
|January 21, 2023
Summary
Lung cancer and pulmonary tuberculosis share symptoms and can influence each other. Pulmonary rehabilitation can improve outcomes for patients with either condition.
Area of Science:
- Oncology
- Infectious Diseases
- Pulmonology
Background:
- Lung cancer and pulmonary tuberculosis are leading global health issues with overlapping symptoms and potential causal links.
- Chronic inflammation and genomic alterations in tuberculosis may promote lung cancer development.
- Lung cancer progression and treatment can trigger latent tuberculosis reactivation.
Purpose of the Study:
- To explore the complex relationship between lung cancer and pulmonary tuberculosis.
- To examine the impact of lung cancer treatments, including checkpoint inhibitors, on tuberculosis reactivation.
- To highlight the role of pulmonary rehabilitation in managing patients with both conditions.
Main Methods:
- Review of existing literature on the interplay between lung cancer and tuberculosis.
- Analysis of the effects of carcinogenesis and cancer treatments on tuberculosis.
- Evaluation of pulmonary rehabilitation strategies for affected patients.
Main Results:
- Tuberculosis-associated inflammation and genetic changes can drive lung cancer.
- Cancer treatments, particularly checkpoint inhibitors, may reactivate tuberculosis.
- Pulmonary rehabilitation shows promise for improving patient outcomes.
Conclusions:
- The bidirectional relationship between lung cancer and tuberculosis necessitates careful management.
- Checkpoint inhibitors present a dual challenge, treating cancer while risking tuberculosis reactivation.
- Pulmonary rehabilitation is a crucial, recommended intervention for patients with lung cancer or post-tuberculosis.
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