Related Experiment Video

Updated: Aug 13, 2025

Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability
07:23

Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability

Published on: August 6, 2021

2.8K

Red Blood Cells: A Newly Described Partner in Central Retinal Vein Occlusion Pathophysiology?

Sandrine Laurance1, Mickaël Marin1, Yves Colin1

  • 1Université Paris Cité and Université des Antilles, INSERM, BIGR, F-75014 Paris, France.

International Journal of Molecular Sciences
|January 21, 2023
PubMed

Insights

Central retinal vein occlusion (CRVO) involves red blood cell (RBC) dysfunction. Understanding RBC roles beyond oxygen transport may reveal new CRVO treatment targets.

Area of Science:

  • Ophthalmology
  • Hematology
  • Vascular Biology

Background:

  • Central retinal vein occlusion (CRVO) is a common cause of vision loss.
  • Current treatments for CRVO address complications, not the underlying causes.
  • The exact pathophysiology of CRVO remains unclear, with no identified primary cause.

Purpose of the Study:

  • To review the pathophysiology of CRVO.
  • To explore the specific role of the erythroid lineage, particularly red blood cells (RBCs), in CRVO.
  • To highlight emerging data on non-oxygen transport functions of RBCs and their vascular impact.

Main Methods:

  • Literature review of studies on CRVO pathophysiology.
  • Analysis of research on red blood cell (RBC) functions and dysfunction.
  • Synthesis of evidence linking RBCs to vascular obstruction in the retina.

Main Results:

  • CRVO is a multifactorial disorder with complex underlying mechanisms.
  • Red blood cells (RBCs) possess functions beyond oxygen transport that can affect vascular health.
  • Emerging evidence suggests a significant involvement of RBC dysfunction in the occurrence of CRVO.

Conclusions:

  • The erythroid lineage, specifically red blood cells (RBCs), plays a crucial role in CRVO pathophysiology.
  • Further research into RBC functions may uncover novel therapeutic targets for CRVO.
  • Understanding RBCs' non-canonical roles is essential for developing effective CRVO treatments.

Keywords:
adhesionerythropoiesisred blood cellvascular occlusionvisual loss

More Related Videos

In Vivo Vascular Injury Readouts in Mouse Retina to Promote Reproducibility07:35

In Vivo Vascular Injury Readouts in Mouse Retina to Promote Reproducibility

Published on: April 21, 2022

2.2K
Oxygen-Induced Retinopathy Model for Ischemic Retinal Diseases in Rodents09:28

Oxygen-Induced Retinopathy Model for Ischemic Retinal Diseases in Rodents

Published on: September 16, 2020

8.6K

Related Concept Videos

Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
23
Anatomy of the Eyeball01:20

Anatomy of the Eyeball

The eye is a spherical, hollow structure composed of three tissue layers. The outer layer — the fibrous tunic, comprises the sclera — a white structure — and the cornea, which is transparent. The sclera encompasses some of the ocular surface, most of which is not visible. However, the 'white of the eye' is distinctively visible in humans compared to other species. The cornea, a clear covering at the front of the eye, enables light penetration. The eye's middle...
7.3K
Veins as Blood Reservoirs01:10

Veins as Blood Reservoirs

Veins, while chiefly responsible for circulating blood back to the heart, also function as storage vessels for blood. They house approximately 64 percent of the body's total blood volume, a feat made possible by their high capacitance—the inherent ability to expand and accommodate large volumes of blood, even under low pressure. The large diameter and thin walls of veins augment their distensibility, significantly more so than arteries, due to their classification as capacitance...
6.1K