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Updated: Aug 13, 2025

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

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COVID-19: Has the Liver Been Spared?

Nicolò Brandi¹, Daniele Spinelli¹, Alessandro Granito²

¹Department of Radiology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Via Albertoni 15, 40138 Bologna, Italy.

International Journal of Molecular Sciences

|January 21, 2023

Summary

The COVID-19 virus can harm the liver, worsening chronic liver disease and complicating treatment for cirrhosis and liver tumors. Telemedicine offers solutions for managing these patients during the pandemic.

Keywords:

COVID-19 chronic liver disease hepatocellular carcinoma liver management

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The Influence of Liver Resection on Intrahepatic Tumor Growth

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Published on: April 9, 2016

Area of Science:

Hepatology
Infectious Diseases
Oncology

Background:

The liver is a secondary target of COVID-19, leading to significant complications.
COVID-19 exacerbates pre-existing chronic liver disease, increasing risks of hepatic decompensation.
The pandemic impacts management of decompensated cirrhosis, hepatocellular carcinoma (HCC), and follow-up care.

Purpose of the Study:

To review hypothesized pathophysiological mechanisms of COVID-19-induced liver injury.
To analyze the pandemic's consequences on patients with chronic liver disease and liver tumors.
To evaluate management strategies for liver disease patients during the COVID-19 emergency.

Main Methods:

Literature review of COVID-19's effects on liver disease.
Analysis of direct viral invasion and indirect effects on liver injury.
Examination of pandemic-related challenges in liver disease management.

Main Results:

COVID-19 can directly cause liver complications and indirectly affect patient management.
Liver imaging in COVID-19 is nonspecific but aids in identifying complications.
Telemedicine presents a viable strategy for overcoming pandemic-related healthcare challenges.

Conclusions:

Understanding COVID-19's multifaceted impact on liver health is crucial.
Improved management strategies are needed for chronic liver disease and liver tumor patients.
Telemedicine can enhance care continuity and accessibility during health crises.