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Bacterial Expression and Purification of Human Matrix Metalloproteinase-3 using Affinity Chromatography
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Metal Complexes as Promising Matrix Metalloproteinases Regulators.
Yen Thi Nguyen1, Namdoo Kim1, Hyuck Jin Lee2
1Department of Chemistry, Kongju National University, Gongju 32588, Chungcheongnam-do, Republic of Korea.
International Journal of Molecular Sciences
|January 21, 2023
Summary
Metal complexes offer a promising therapeutic strategy for cancer and Alzheimer's disease (AD). These compounds effectively target matrix metalloproteinases (MMPs), crucial in disease progression, presenting a novel approach for treating these fatal conditions.
Area of Science:
- Biochemistry
- Pharmacology
- Oncology
Background:
- Cancers and Alzheimer's disease (AD) are leading causes of mortality.
- Matrix metalloproteinases (MMPs), particularly MMP-2 and MMP-9, are implicated in the pathogenesis of cancer and AD.
- Targeting MMPs is a potential therapeutic strategy for these diseases.
Purpose of the Study:
- To review recent advancements in metal complexes as regulators of MMPs.
- To explore the potential of metal complexes in treating cancer and AD.
- To highlight the advantages of metal complexes, including synthesis, toxicity, and specificity.
Main Methods:
- Literature review of studies on metal complexes targeting MMPs.
- Analysis of various metal complexes, including Pt-, Ru-, Au-, Fe-, Cu-, Ni-, Zn-, and Sn-complexes.
- Evaluation of the role of MMPs in cancer and AD pathology.
Main Results:
- Metal complexes demonstrate potential in regulating MMPs activity and expression.
- Specific metal complexes show promise for therapeutic applications in cancer and AD.
- Advantages such as simple synthesis, reduced toxicity, and target specificity are noted.
Conclusions:
- Metal complexes represent a promising class of therapeutic agents for cancer and AD.
- Targeting MMPs with metal complexes offers a novel strategy for disease management.
- Further research into metal complexes could lead to effective treatments for these fatal diseases.
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