Platelet-Neutrophil Crosstalk in Thrombosis
Laura J Mereweather1, Adela Constantinescu-Bercu1, James T B Crawley1
1Centre for Haematology, Department of Immunology and Inflammation, Imperial College London, London W12 0NN, UK.
International Journal of Molecular Sciences
|January 21, 2023
Summary
Platelets and neutrophils are key in blood clot formation and immunity. Their interaction, termed immunothrombosis, drives cardiovascular diseases and COVID-19, offering new therapeutic targets.
Area of Science:
- Hematology
- Immunology
- Cardiovascular Medicine
Background:
- Platelets are vital for hemostasis, forming clots to prevent bleeding.
- Neutrophils are crucial immune cells defending against pathogens.
- The interaction between platelets and neutrophils (immunothrombosis) plays a role in cardiovascular diseases and infections like COVID-19.
Purpose of the Study:
- To review the complex crosstalk between platelets and neutrophils.
- To elucidate the role of this interaction in arterial and venous thrombosis, and COVID-19.
- To explore novel therapeutic strategies targeting platelet-neutrophil interactions for thrombosis treatment.
Main Methods:
- Literature review focusing on platelet-neutrophil interactions.
- Analysis of existing research on immunothrombosis in cardiovascular diseases and COVID-19.
- Discussion of current antithrombotic therapies and their limitations.
Main Results:
- Platelet-neutrophil crosstalk is central to both arterial and venous thrombosis.
- This interaction contributes significantly to the thrombotic burden in cardiovascular diseases and COVID-19.
- Current antithrombotic strategies targeting platelets or coagulation carry bleeding risks.
Conclusions:
- Targeting platelet-neutrophil interactions offers a promising approach to treat thrombosis.
- Novel therapies could reduce thrombosis risk without compromising hemostasis.
- Modulating platelet-mediated neutrophil recruitment may provide safer antithrombotic treatments.
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