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CD96 as a Potential Immune Regulator in Cancers

Shikai Feng1, Orkhan Isayev2, Jens Werner1,3,4

  • 1Department of General, Visceral and Transplant Surgery, Ludwig-Maximilians-University Munich, 81377 Munich, Germany.

International Journal of Molecular Sciences
|January 21, 2023
PubMed

Insights

Researchers are exploring novel immune checkpoint targets for cancer immunotherapy. This review focuses on CD96, a promising but understudied molecule, highlighting its biology and therapeutic potential in cancer treatment.

Area of Science:

  • Immunology
  • Oncology
  • Molecular Biology

Background:

  • Immune checkpoints like CTLA-4 and PD-1 are key targets in cancer immunotherapy.
  • Nectin and nectin-like proteins represent emerging targets for cancer therapies.
  • CD226, TIGIT, and CD96 are immune checkpoints within this receptor class.

Purpose of the Study:

  • To review the fundamental biology of CD96.
  • To discuss recent research on CD96 as a cancer immunotherapy target.
  • To highlight CD96's potential in the field of oncology.

Main Methods:

  • Literature review of scientific publications.
  • Analysis of basic CD96 biology.
  • Synthesis of recent research findings on CD96 in cancer.

Main Results:

  • CD96 is an under-investigated immune checkpoint molecule.
  • Emerging research suggests CD96's role in cancer immunity.
  • CD96 presents a novel target for therapeutic development.

Conclusions:

  • CD96 warrants further investigation for its role in cancer immunotherapy.
  • Targeting CD96 may offer new treatment strategies for cancer patients.
  • Continued research is crucial to unlock CD96's full therapeutic potential.
Keywords:
CD155CD226CD96TIGITimmune checkpoint moleculesimmune modulation

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