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Concern about the Effectiveness of mRNA Vaccination Technology and Its Long-Term Safety: Potential Interference on

Gianmarco Stati1, Paolo Amerio1, Mario Nubile2

  • 1Department of Medicine and Ageing Sciences, G. d'Annunzio University of Chieti-Pescara, Via dei Vestini, 31, 66100 Chieti, Italy.

International Journal of Molecular Sciences
|January 21, 2023
PubMed

Insights

The effectiveness and safety of mRNA COVID-19 vaccines, particularly against the omicron variant, are under scrutiny. Research explores the role of miRNA machinery in vaccine response and potential long-term health implications.

Area of Science:

  • Immunology
  • Virology
  • Molecular Biology

Background:

  • The COVID-19 pandemic spurred rapid mRNA vaccine development under Emergency Use Authorization (EUA).
  • The SARS-CoV-2 omicron variant (Ba.5) is currently dominant, raising concerns about vaccine effectiveness due to its high transmissivity and mutable genome.
  • MicroRNA (miRNA) machinery regulates cellular processes and its dysregulation is linked to COVID-19 complications and diseases like cancer.

Purpose of the Study:

  • To evaluate the effectiveness of mRNA COVID-19 vaccines against the prevalent omicron variant.
  • To investigate the long-term safety profile of mRNA COVID-19 vaccines, especially after multiple doses.
  • To explore the role of miRNA machinery in the host's response to mRNA vaccination and its potential implications.

Main Methods:

  • Analysis of existing data on vaccine efficacy against omicron variants.
  • Review of studies on miRNA dysregulation in COVID-19 patients.
  • Examination of potential links between miRNA machinery and vaccine-induced immune responses.
  • Assessment of reported adverse events and long-term safety data following mRNA vaccination.

Main Results:

  • Preliminary concerns exist regarding the effectiveness of current mRNA vaccines against the highly transmissible omicron variant.
  • The role of miRNA machinery in modulating vaccine response requires further investigation.
  • Long-term safety data are still being gathered, necessitating continued monitoring.

Conclusions:

  • Ongoing research is crucial to confirm the sustained effectiveness of mRNA vaccines against evolving SARS-CoV-2 variants.
  • Understanding the intricate role of miRNA machinery may offer insights into vaccine response and potential adverse effects.
  • Long-term surveillance is essential to ensure the safety and efficacy of widespread mRNA vaccination programs.
Keywords:
BNT162b2COVID-19SARS-CoV-2cancerinnovative formulationmRNA vaccinesmRNA1273miRNAs

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