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Antimicrobial and Virucidal Potential of Morpholinium-Based Ionic Liquids
Jakub Michalski1, Julia Sommer2,3, Peter Rossmanith2,4
1Department of Biochemistry and Biotechnology, Poznań University of Life Sciences, Dojazd 11, 60-632 Poznan, Poland.
International Journal of Molecular Sciences
|January 21, 2023
Summary
Ionic liquids (ILs) show promise as novel antimicrobials and antivirals. Certain morpholinium-based ILs effectively inhibited viruses and bacteria, with activity linked to alkyl chain length and viral structure.
Area of Science:
- Antimicrobial and antiviral research
- Green chemistry
- Materials science
Background:
- The rise of antimicrobial resistance and viral pandemics necessitates new disinfection strategies.
- Ionic liquids (ILs) are recognized for their antimicrobial properties and potential antiviral applications.
Purpose of the Study:
- To evaluate the antiviral and antimicrobial efficacy of 12 morpholinium-based herbicidal ionic liquids.
- To investigate the structure-activity relationships of ILs against bacteria and viruses.
Main Methods:
- Enzyme inhibition assays
- Virucidal activity tests against five model viruses (Phi6, PRD1, MS2, P100, P001)
- Antimicrobial activity tests against five bacterial species
Main Results:
- Antimicrobial and enzyme inhibition correlated with the length of alkyl side chains in ILs.
- [Dec2Mor]+ based ILs demonstrated significant antimicrobial potential.
- Antiviral activity varied by virus type; enveloped Phi6 phage was susceptible, while non-enveloped phages (PRD1, MS2) were resistant.
- Viral susceptibility to ILs was influenced by viral structure, including phage tail differences.
Conclusions:
- Morpholinium-based ILs are promising candidates for novel antimicrobial and antiviral agents.
- ILs efficacy is dependent on both the IL structure and the target virus's characteristics.
- Further research into ILs for disinfection and therapeutic applications is warranted.
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