Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

T Cell Types and Functions

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Theophylline Inhibits Capillary Degeneration in Early Diabetic Retinopathy.

Investigative ophthalmology & visual science·2026

Same author

Expanding Access to Retinal Imaging Through Patient-Operated Optical Coherence Tomography in a Veterans Affairs Retina Clinic.

Bioengineering (Basel, Switzerland)·2026

Same author

Diabetes-Mediated STEAP4 Enhances Retinal Oxidative Stress and Impacts the Development of Diabetic Retinopathy.

Antioxidants (Basel, Switzerland)·2025

Same author

Optic nerve injury impairs intrinsic mechanisms underlying electrical activity in a resilient retinal ganglion cell.

The Journal of physiology·2025

Same author

Early exposure to Western Diet exacerbates visual outcomes in female mice.

bioRxiv : the preprint server for biology·2024

Same author

Quantifying the Corneal Nerve Whorl Pattern.

Translational vision science & technology·2024

Search research articles

Related Experiment Video

Updated: Aug 13, 2025

Assessment of Vascular Regeneration in the CNS Using the Mouse Retina

Assessment of Vascular Regeneration in the CNS Using the Mouse Retina

Published on: June 23, 2014

IL-17A Enhances Retinal Neovascularization.

Brooklyn E Taylor¹, Chieh A Lee¹, Thomas E Zapadka^1,2

¹Department of Ophthalmology and Visual Science, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.

International Journal of Molecular Sciences

|January 21, 2023

Summary

This summary is machine-generated.

Interleukin-17A (IL-17A) drives retinal neovascularization in ocular diseases like diabetic retinopathy. Targeting IL-17A may offer new therapies for vision loss caused by retinal angiogenesis.

Keywords:

IL-17A neovascularization retina

More Related Videos

Retinal Explant of the Adult Mouse Retina as an Ex Vivo Model for Studying Retinal Neurovascular Diseases

Retinal Explant of the Adult Mouse Retina as an Ex Vivo Model for Studying Retinal Neurovascular Diseases

Published on: December 9, 2022

Characterization of a Novel Human Organotypic Retinal Culture Technique

Characterization of a Novel Human Organotypic Retinal Culture Technique

Published on: June 9, 2021

Related Experiment Videos

Last Updated: Aug 13, 2025

Assessment of Vascular Regeneration in the CNS Using the Mouse Retina

Assessment of Vascular Regeneration in the CNS Using the Mouse Retina

Published on: June 23, 2014

Retinal Explant of the Adult Mouse Retina as an Ex Vivo Model for Studying Retinal Neurovascular Diseases

Retinal Explant of the Adult Mouse Retina as an Ex Vivo Model for Studying Retinal Neurovascular Diseases

Published on: December 9, 2022

Characterization of a Novel Human Organotypic Retinal Culture Technique

Characterization of a Novel Human Organotypic Retinal Culture Technique

Published on: June 9, 2021

Area of Science:

Ophthalmology
Immunology
Vascular Biology

Background:

Retinal neovascularization is a major cause of vision loss in diseases such as diabetic retinopathy.
Interleukin-17A (IL-17A) is implicated in non-proliferative diabetic retinopathy, but its role in proliferative stages was unclear.

Purpose of the Study:

To investigate the role of IL-17A in vascular angiogenesis and neovascularization in the retina.
To determine if IL-17A contributes to the development of proliferative diabetic retinopathy.

Main Methods:

Assessed IL-17A's effect on vascular endothelial growth factor (VEGF) production in retinal cells.
Examined IL-17A's impact on retinal endothelial cell proliferation and VEGF-dependent angiogenesis.
Utilized an oxygen-induced retinopathy model to study IL-17A's role in retinal neovascularization.

Main Results:

Diabetes-mediated IL-17A enhances VEGF production in retinal cells, Muller glia, and endothelial cells.
IL-17A promotes retinal endothelial cell proliferation and VEGF-driven vascular angiogenesis.
IL-17A significantly increases retinal neovascularization in an oxygen-induced retinopathy model.

Conclusions:

IL-17A plays a critical role in retinal vascular proliferation and neovascularization.
IL-17A represents a potential therapeutic target for treating blinding ocular neovascular diseases.