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Chitosan Composites Containing Boron-Dipyrromethene Derivatives for Biomedical Applications
Aleksander Smolarkiewicz-Wyczachowski1, Halina Kaczmarek1, Jaroslaw Piskorz2
1Faculty of Chemistry, Nicolaus Copernicus University in Torun, Gagarina 7, 87-100 Torun, Poland.
International Journal of Molecular Sciences
|January 21, 2023
Summary
This study developed photosensitive chitosan composites with BODIPY dyes for photodynamic therapy. The composites show enhanced protein interaction and tunable dye release, influenced by iodine content in the dyes.
Area of Science:
- Biomaterials Science
- Photochemistry
- Polymer Chemistry
Background:
- Chitosan is a versatile biopolymer with applications in biomedicine.
- Photosensitive dyes are crucial for photodynamic therapy (PDT).
- Developing effective drug delivery systems for PDT remains a challenge.
Purpose of the Study:
- To prepare and characterize photosensitive chitosan-BODIPY dye composites for potential PDT applications.
- To investigate the spectral, surface, and morphological properties of these novel materials.
- To evaluate protein absorption and dye release kinetics from the chitosan matrix.
Main Methods:
- Solution casting method for preparing chitosan films with 5% BODIPY dyes.
- Spectroscopic analysis (IR, UV-Vis, fluorescence) for spectral properties.
- Contact angle, SEM, and AFM for surface and morphological characterization.
- Protein absorption assays and dye release studies in methanol.
Main Results:
- Chitosan-BODIPY composites exhibited increased hydrophilicity, heterogeneity, and roughness compared to pure chitosan.
- Iodine in BODIPY dyes induced a bathochromic shift but reduced emission quantum yield.
- Composites demonstrated enhanced interaction with human serum albumin and acidic α-glycoprotein.
- Dye release rate was dependent on the iodine content in the BODIPY structure.
Conclusions:
- Photosensitive chitosan-BODIPY composites are promising materials for photodynamic therapy.
- The presence of iodine in BODIPY dyes influences spectral properties and dye release kinetics.
- These composites show improved biocompatibility due to enhanced protein interactions.
