Related Experiment Video

Updated: Aug 13, 2025

Analysis of the Ambient Particulate Matter-induced Chromosomal Aberrations Using an In Vitro System
08:48

Analysis of the Ambient Particulate Matter-induced Chromosomal Aberrations Using an In Vitro System

Published on: December 21, 2016

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The Road to Malignant Cell Transformation after Particulate Matter Exposure: From Oxidative Stress to Genotoxicity

Miguel Santibáñez-Andrade1, Ericka Marel Quezada-Maldonado1, Andrea Rivera-Pineda1,2

  • 1Subdirección de Investigación Básica, Instituto Nacional de Cancerología, San Fernando No. 22, Tlalpan, México City CP 14080, Mexico.

International Journal of Molecular Sciences
|January 21, 2023
PubMed

Insights

Particulate matter (PM) air pollution causes oxidative stress and genotoxicity, contributing to cancer development. Understanding these mechanisms is key to developing new strategies for studying PM-associated tumors.

Area of Science:

  • Cellular Biology
  • Environmental Health
  • Toxicology

Background:

  • Oxidative stress, an imbalance in oxidant levels and antioxidant capacity, leads to cellular damage via reactive oxygen species (ROS).
  • ROS interact with lipids, proteins, and DNA, causing genotoxic damage that can initiate mutations and malignant transformation.
  • Chronic oxidative stress is implicated in all stages of cancer: initiation, promotion, and progression.

Purpose of the Study:

  • To review the role of oxidative and genotoxic mechanisms induced by particulate matter (PM) in malignant cell transformation.
  • To discuss novel approaches for accurately studying PM-associated tumor development.
  • To emphasize the significance of oxidative stress and genotoxicity in PM's carcinogenic potential.

Main Methods:

  • Review of epidemiological and toxicological evidence on PM-induced carcinogenesis.
  • Analysis of mechanisms linking PM exposure to cancer hallmarks.
  • Discussion of emerging research methodologies.

Main Results:

  • Particulate matter (PM) is a recognized cancer risk factor, increasing tumor incidence.
  • PM-induced oxidative stress mediates key events in carcinogenesis, including proliferative signaling, evasion of growth suppression, resistance to cell death, angiogenesis, and invasion/metastasis.
  • Oxidative and genotoxic pathways are central to PM's role in malignant transformation.

Conclusions:

  • Oxidative stress and genotoxicity are critical mechanisms by which PM contributes to cancer.
  • Further research into these pathways is essential for understanding and mitigating PM-related cancer risks.
  • Developing accurate methods to study PM-associated tumors is crucial for assessing the impact of oxidative stress and genotoxicity.
Keywords:
air pollutioncancergenotoxicityoxidative stressparticulate matter

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