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Factors Associating with Non-Dipping Pattern of Nocturnal Blood Pressure in Patients with Essential Hypertension

Tsutomu Koike1, Teruhiko Imamura1, Fumihiro Tomoda2

  • 1Second Department of Internal Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.

Journal of Clinical Medicine
|January 21, 2023
PubMed

Insights

Essential hypertension patients with a non-dipping blood pressure pattern may have higher serum uric acid levels. This suggests hyperuricemia and inflammation could be linked to reduced nocturnal blood pressure dipping.

Area of Science:

  • Cardiology
  • Nephrology
  • Hypertension Research

Background:

  • Non-dipping blood pressure pattern in essential hypertension is a significant risk factor for cardiovascular diseases.
  • The underlying factors contributing to this blood pressure pattern are not fully understood.

Purpose of the Study:

  • To investigate clinical factors associated with non-dipper status in untreated essential hypertensive patients.
  • To explore the relationship between serum uric acid, inflammation, and nocturnal blood pressure dipping.

Main Methods:

  • Included 154 untreated essential hypertensive patients without chronic kidney disease.
  • Performed blood sampling and 24-hour ambulatory blood pressure monitoring.
  • Defined non-dipper status as a maximum decrease in nocturnal systolic blood pressure within 10%.

Main Results:

  • Higher serum uric acid levels were independently associated with non-dipper status (OR 1.03, p < 0.05).
  • Higher high-sensitivity C-reactive protein levels showed a trend towards association with increased nighttime systolic blood pressure (p = 0.065).

Conclusions:

  • Hyperuricemia may be linked to attenuated nocturnal blood pressure dipping in essential hypertension.
  • Micro-inflammation might also play a role in reduced nocturnal blood pressure dipping and increased nighttime systolic blood pressure.

Keywords:
hemodynamicshypertensionoxidative stress

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