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Prognostic Potential of Cyclin D1 Expression in Colorectal Cancer

Sun-Young Jun1, Jiyoung Kim1, Nara Yoon1

  • 1Department of Pathology, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Incheon 21431, Republic of Korea.

Journal of Clinical Medicine
|January 21, 2023
PubMed

Insights

High cyclin D1 expression in colorectal cancer (CRC) is common and predicts better survival. This finding is crucial for understanding patient prognosis and potential response to targeted therapies like CDK4/6 inhibitors.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Cyclin D1 is recognized as an oncogenic driver in various cancers.
  • The cyclin D1/cyclin-dependent kinase (CDK) 4/6 pathway is a key therapeutic target.
  • The prognostic role of cyclin D1 in colorectal cancer (CRC) remains debated.

Purpose of the Study:

  • To investigate the association between cyclin D1 expression and clinicopathological factors in CRC.
  • To evaluate cyclin D1 as a prognostic biomarker for overall survival (OS) and recurrence-free survival (RFS) in CRC patients.
  • To analyze previous studies on cyclin D1 in CRC.

Main Methods:

  • Retrospective analysis of 495 surgically resected primary CRC cases.
  • Assessment of cyclin D1 expression levels.
  • Correlation analysis with clinicopathological factors, OS, and RFS.
  • Multivariate analysis to identify independent prognosticators.

Main Results:

  • High cyclin D1 expression (cyclin D1High) was found in 78.6% of CRC cases.
  • Cyclin D1High was consistently associated with better OS and RFS.
  • Independent predictors for higher OS included cyclin D1High and younger patient age.
  • Independent predictors for better RFS included cyclin D1High, female sex, chemotherapy, absence of nodal metastasis, and lower T-category.

Conclusions:

  • Cyclin D1 is frequently overexpressed in colorectal cancer.
  • Elevated cyclin D1 expression serves as a favorable prognostic indicator in CRC patients.
  • These findings may guide the prediction of treatment response to CDK4/6 inhibitors.
Keywords:
adenocarcinomacoloncyclin D1immunohistochemistrysurvival

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