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Direct Oral Anticoagulants for Stroke and Systemic Embolism Prevention in Patients with Left Ventricular Thrombus

Minerva Codruta Badescu1,2, Victorita Sorodoc1,3, Catalina Lionte1,3

  • 1Department of Internal Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.

Journal of Personalized Medicine
|January 21, 2023
PubMed

Insights

Direct oral anticoagulants (DOACs) show promise for treating left ventricular thrombus, despite limited evidence and off-label use. This review analyzes their safety and efficacy in this specific patient group.

Area of Science:

  • Cardiology
  • Pharmacology
  • Thrombosis Research

Background:

  • Direct oral anticoagulants (DOACs) are increasingly used for various indications due to proven efficacy and safety.
  • Current guidelines lack specific recommendations for DOACs in left ventricular thrombus (LVT).
  • Off-label use of DOACs for LVT is prevalent due to a scarcity of dedicated clinical evidence.

Purpose of the Study:

  • To provide a comprehensive literature review on the use of DOACs in patients with LVT.
  • To analyze the safety and efficacy of DOACs in managing LVT.
  • To offer a structured update for clinicians regarding DOACs for LVT.

Main Methods:

  • Exhaustive analysis of existing medical literature.
  • Systematic review of studies investigating DOACs in LVT patients.
  • Evaluation of safety and efficacy data across different clinical contexts.

Main Results:

  • DOACs demonstrate potential efficacy and safety in managing LVT, though evidence remains limited.
  • Analysis highlights specific clinical scenarios where DOACs may be beneficial for LVT.
  • This study represents a novel, in-depth analysis of DOACs specifically for LVT.

Conclusions:

  • DOACs represent a potential therapeutic option for left ventricular thrombus.
  • Further research and clinical trials are warranted to establish definitive guidelines for DOAC use in LVT.
  • This review provides valuable insights into the current understanding and application of DOACs for LVT.

Keywords:
COVID-19direct oral anticoagulantshypertrophic cardiomyopathyleft ventricular thrombusmyocarditis

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