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Updated: Aug 13, 2025
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Evaluation of LC3-II Release via Extracellular Vesicles in Relation to the Accumulation of Intracellular LC3-positive Vesicles
Published on: October 18, 2024
766
Extracellular Vesicles in Amyotrophic Lateral Sclerosis.
Gavin McCluskey1,2,3, Karen E Morrison3,4, Colette Donaghy2
1Personalised Medicine Centre, School of Medicine, Ulster University, Derry BT47 6SB, UK.
Life (Basel, Switzerland)
|January 21, 2023
Summary
Extracellular vesicles (EVs) play a crucial role in Amyotrophic Lateral Sclerosis (ALS) pathogenesis by spreading toxic proteins and offering potential therapeutic strategies. Research explores EV dysregulation and their use in ALS treatment.
Area of Science:
- Neuroscience
- Cell Biology
- Biochemistry
Background:
- Amyotrophic Lateral Sclerosis (ALS) is a common adult motor neuron disease with complex pathogenesis.
- Multiple cellular pathways, including extracellular vesicle (EV) secretion, are implicated in ALS.
- EVs are key mediators of intercellular communication, transporting proteins, lipids, and genetic material.
Purpose of the Study:
- To review the biogenesis and multifaceted roles of EVs in ALS.
- To examine the involvement of ALS-related genes in EV formation and trafficking.
- To discuss the diagnostic potential of EV dysregulation and therapeutic applications of EVs in ALS.
Main Methods:
- Literature review of EV biogenesis, function, and relevance in ALS.
- Analysis of studies on pathological protein propagation via EVs in ALS.
- Examination of genetic factors, biomarkers, and therapeutic strategies involving EVs in ALS.
Main Results:
- EVs contribute to the propagation of misfolded proteins like TDP-43, SOD1, and FUS in ALS.
- ALS-related genes influence EV formation and vesicular transport.
- Aberrant EV protein and RNA profiles in ALS show potential as biomarkers.
Conclusions:
- EVs are significantly involved in ALS progression and pathology.
- EVs present promising avenues for ALS biomarker discovery and therapeutic interventions, including stem cell-derived EVs and drug delivery systems.
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