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Exploring the Bioactive Mycocompounds (Fungal Compounds) of Selected Medicinal Mushrooms and Their Potentials against

Tomas Rokos1, Terezia Pribulova1, Erik Kozubik1

  • 1Department of Gynecology and Obstetrics, Jessenius Faculty of Medicine, Comenius University in Bratislava, Mala Hora 4A, 036 01 Martin, Slovakia.

Life (Basel, Switzerland)
|January 21, 2023
PubMed

Insights

Medicinal mushrooms like Coriolus versicolor show promise in fighting cancers, particularly those caused by human papillomavirus (HPV). Extracts can inhibit cancer cell growth and improve HPV clearance, acting as a valuable adjunct therapy.

Area of Science:

  • Mycology
  • Immunology
  • Oncology

Background:

  • Medicinal mushrooms have a long history of use in disease prevention and therapy.
  • Infectious agents, such as human papillomavirus (HPV), are linked to a significant percentage of cancer cases.
  • Coriolus versicolor contains active compounds like polysaccharide-K (PSK) and polysaccharopeptide (PSP) with anti-cancer properties.

Purpose of the Study:

  • To review the use of medicinal mushrooms as an adjunct therapy for various cancers.
  • To explore the potential of Coriolus versicolor in combating HPV-related cancers.
  • To assess the role of medicinal mushrooms in enhancing cancer treatment efficacy and vaccination.

Main Methods:

  • Review of scientific literature on medicinal mushrooms and their anti-cancer mechanisms.
  • Analysis of studies investigating Coriolus versicolor extracts and their effects on cancer cell lines (e.g., HeLa, breast tumor cells).
  • Examination of clinical data on the use of Coriolus versicolor in HPV-positive patients and its impact on cervical cytology.

Main Results:

  • Coriolus versicolor extracts demonstrate anti-cancer effects by arresting cell cycles, modulating immunity, and inducing apoptosis.
  • Extracts can reduce BCL-2 expression and increase p53 tumor suppressor gene expression in breast cancer cells.
  • Studies show inhibition of proliferation in HeLa cells and improved cervical cytology with Coriolus versicolor vaginal gel.
  • Coriolus versicolor, alone or with Ganoderma lucidum, improves HPV clearance in patients.

Conclusions:

  • Medicinal mushrooms, especially Coriolus versicolor, are effective adjuncts in treating various cancers and precanceroses.
  • Coriolus versicolor shows significant potential in managing HPV-related cancers.
  • These mushrooms can enhance the effectiveness of conventional cancer treatments and vaccinations.
Keywords:
HPVcervical dysplasiamedicinal mushrooms

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