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Bonding behavior between two bioactive ceramics in vivo.

T Kitsugi1, T Yamamuro, T Nakamura

  • 1Department of Orthopaedic Surgery, Faculty of Medicine, Kyoto University, Japan.

Journal of Biomedical Materials Research
|September 1, 1987
PubMed
Summary
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Bioactive ceramics, including apatite-wollastonite glass-ceramics and hydroxyapatite, demonstrate in vivo self-repair capabilities. A calcium-phosphorus-rich layer facilitates bonding between implanted ceramic specimens in rats.

Area of Science:

  • Biomaterials Science
  • Materials Science
  • Bioceramics Research

Background:

  • Understanding in vivo chemical bonding mechanisms of bioactive ceramics is crucial for developing effective bone regeneration materials.
  • Previous studies have explored the bioactivity of ceramics, but the self-repair potential under various conditions requires further investigation.

Purpose of the Study:

  • To investigate the chemical bonding mechanisms of bioactive ceramics, specifically apatite-wollastonite glass-ceramics (A.W-GC) and hydroxyapatite (HA), in vivo.
  • To determine the influence of sintering temperature and binding methods on the self-repair and bonding of these ceramics.

Main Methods:

  • Two in vivo experiments were conducted using subcutaneous implantation in rats.
  • Specimens of A.W-GC and HA with varying sintering temperatures and porosities were implanted, some bound with silk thread and others not.

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  • Scanning Electron Microscopy with Electron Probe Microanalysis (SEM-EPMA) was used to analyze the interface between specimens.

    • Main Results:

    • Bound A.W-GC specimens showed bonding at 3 and 6 months, with a Ca-P-rich layer forming at the interface.
    • Both bound and non-bound A.W-GC exhibited similar bonding results after 1 month.
    • Hydroxyapatite sintered at 800°C and 1000°C showed bonding in all specimens, attributed to chemical changes influenced by sintering temperature, with a Ca-P-rich layer observed.

    Conclusions:

    • Bioactive ceramics possess self-repair capabilities under specific in vivo conditions.
    • The formation of a Ca-P-rich layer is a key factor in the observed bonding between ceramic specimens.
    • Sintering temperature significantly influences the in vivo bonding behavior of hydroxyapatite.