Related Experiment Video

Updated: Aug 13, 2025

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch
08:51

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch

Published on: August 24, 2019

10.1K

Appendiceal Carcinoids in Children-Prevalence, Treatment and Outcome in a Large Nationwide Pediatric Cohort

Johannes Wolfgang Duess1, Ansgar Lange2, Jan Zeidler2

  • 1Department of Pediatric Surgery, University of Leipzig, 04103 Leipzig, Germany.

Medicina (Kaunas, Lithuania)
|January 21, 2023
PubMed

Insights

Appendiceal carcinoids, rare pediatric neuroendocrine tumors, were found in 0.11% of appendectomies. Most children received only appendectomy, but treatment varied, necessitating further study.

Area of Science:

  • Pediatric Oncology
  • Gastrointestinal Surgery
  • Pathology

Background:

  • Appendiceal carcinoids are rare neuroendocrine tumors often discovered incidentally after appendectomy.
  • Prevalence, treatment, and outcomes in pediatric cases are not well-established.

Purpose of the Study:

  • To determine the prevalence of appendiceal carcinoid tumors in children.
  • To analyze treatment modalities and outcomes in pediatric patients.

Main Methods:

  • Observational cohort study analyzing 8 years of data from a large German health insurance database.
  • Included patient demographics, surgical techniques, departmental data, diagnostic work-up, and postoperative morbidity.

Main Results:

  • Appendiceal carcinoids were identified in 44 out of 40,499 pediatric appendectomy cases (0.11% prevalence).
  • The mean age was 14.7 years; 91% underwent laparoscopic appendectomy.
  • Only 18% required right-sided hemicolectomy, and 11% had additional imaging (CT/MRI).

Conclusions:

  • Appendiceal neuroendocrine tumors are rare in children, with a prevalence of 0.11%.
  • Appendectomy alone was the primary treatment for most pediatric patients.
  • Treatment approaches remain variable, highlighting the need for longer follow-up and guideline evaluation for limited surgical strategies.

Keywords:
appendixcarcinoidchildrenfollow-upprevalencesurgical approach

More Related Videos

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery06:46

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Published on: September 27, 2024

320
Application of Robot-assisted Pancreaticobiliary Junction Resection in Benign Duodenal Tumors03:37

Application of Robot-assisted Pancreaticobiliary Junction Resection in Benign Duodenal Tumors

Published on: December 20, 2024

594

Related Concept Videos

Appendicitis-II: Diagnostic Studies and Management01:29

Appendicitis-II: Diagnostic Studies and Management

Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
113
Appendicitis-I: Introduction01:22

Appendicitis-I: Introduction

The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
363
Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
247
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
185
Cancer Survival Analysis01:21

Cancer Survival Analysis

Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
411