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Polymer Kernels as Compact Carriers for Suspended Cardiomyocytes.

Mikhail Slotvitsky1,2, Andrey Berezhnoy1,2, Serafima Scherbina1

  • 1Moscow Institute of Physics and Technology, Institutskiy Lane 9, 141700 Dolgoprudny, Russia.

Micromachines
|January 21, 2023
PubMed
Summary
This summary is machine-generated.

Smart biomaterials, such as polymer kernels, can improve the survival and integration of injected cardiomyocytes (cardiac cells). This technology enhances cell adhesion and electrophysiological coupling for better cardiac cell replacement therapy.

Keywords:
cell culturingelectrophysiological couplingelectrospinningiPSC-CMpolymers

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Area of Science:

  • Biomaterials Science
  • Cardiovascular Research
  • Stem Cell Biology

Background:

  • Induced pluripotent stem cells (iPSCs) offer patient-specific cardiomyocytes for cardiac repair, avoiding immune rejection.
  • Intramyocardial injection of cardiomyocytes faces challenges in cell survival and electrophysiological coupling with host tissue.
  • Current cell suspension methods lack control over cell adhesion and integration.

Purpose of the Study:

  • To investigate the use of polymer kernels to enhance cardiomyocyte survival and integration after intramyocardial injection.
  • To demonstrate the ability of polymer kernels to promote cell adhesion and electrophysiological coupling.
  • To establish a proof of concept for controlling cell engraftment using smart biomaterials.

Main Methods:

  • Utilizing biocompatible, subcellular-sized polymer fiber fragments (kernels) adsorbed onto cardiomyocytes.
  • Employing optical excitation markers to assess cardiomyocyte excitability.
  • Evaluating in vitro electrophysiological coupling between polymer kernel-modified cardiomyocytes.

Main Results:

  • Polymer kernels were successfully adsorbed to cardiomyocytes, forming adhesion foci and supporting cellular structure.
  • Restoration of cardiomyocyte excitability in suspension was observed upon polymer kernel adsorption.
  • Increased likelihood of stable electrophysiological coupling in vitro was achieved.

Conclusions:

  • Polymer kernels can be used to influence cell adhesion and electrophysiological coupling of injected cardiomyocytes.
  • This approach offers a potential strategy to control the stochastic engraftment of suspension cells.
  • Smart biomaterials show promise for improving cardiac cell replacement therapies.