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Related Experiment Video

Updated: Aug 13, 2025

Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors

Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors

Published on: May 9, 2025

HIV and Drug-Resistant Subtypes.

Bianca Maria Nastri¹, Pasquale Pagliano^2,3, Carla Zannella¹

¹Department of Experimental Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.

|January 21, 2023

Summary

This summary is machine-generated.

Drug-resistant strains of Human Immunodeficiency Virus (HIV) pose a significant challenge to Acquired Immunodeficiency Syndrome (AIDS) treatment. This review explores current information on HIV-1 and HIV-2 drug resistance mutations, highlighting the need for novel therapeutic strategies.

Keywords:

AIDS ART HIV INSTIs NNRTIs NRTIs PIs drug resistance entry inhibitors retrovirus

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Last Updated: Aug 13, 2025

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An Affordable HIV-1 Drug Resistance Monitoring Method for Resource Limited Settings

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Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors

Published on: April 9, 2014

Area of Science:

Virology
Immunology
Pharmacology

Background:

Acquired Immunodeficiency Syndrome (AIDS) is caused by the Human Immunodeficiency Virus (HIV).
Antiretroviral therapy (ART) is the standard treatment, utilizing drugs from various classes to manage HIV infection.
The emergence of drug-resistant HIV strains presents a major clinical challenge, impacting treatment efficacy.

Purpose of the Study:

To review updated information on drug-resistant strains of HIV-1 and HIV-2.
To detail the specific mutations responsible for conferring antiretroviral drug resistance.
To underscore the necessity for exploring novel treatment approaches against resistant HIV.

Main Methods:

Literature review of current research on HIV drug resistance.
Analysis of genetic mutations associated with resistance to different ART drug classes.
Synthesis of information on the prevalence and impact of resistant HIV strains.

Main Results:

HIV-1 and HIV-2 exhibit diverse resistance profiles due to various mutations.
Drug resistance can affect treatment outcomes even in patients undergoing ART.
Geographic distribution and mortality rates vary among resistant HIV outbreaks.

Conclusions:

Drug-resistant HIV strains necessitate ongoing research and development of new therapeutic strategies.
Understanding resistance mechanisms is crucial for effective HIV management.
Novel treatment approaches are essential to overcome the challenge of multidrug-resistant HIV.