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Protocol to Create Chronic Wounds in Diabetic Mice
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A Comprehensive Review on Bio-Based Materials for Chronic Diabetic Wounds

Jinjin Pei1, Chella Perumal Palanisamy2,3, Phaniendra Alugoju4

  • 1Qinba State Key Laboratory of Biological Resources and Ecological Environment, 2011 QinLing-Bashan Mountains Bioresources Comprehensive Development C. I. C, Shaanxi Province Key Laboratory of Bioresources, College of Bioscience and Bioengineering, Shaanxi University of Technology, Hanzhong 723001, China.

Molecules (Basel, Switzerland)
|January 21, 2023
PubMed

Insights

Bio-based materials show promise for improving wound healing by addressing factors like infection and inflammation. This review explores their mechanisms and potential for chronic wound therapies.

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Wound Healing Research

Background:

  • Millions suffer from poor wound healing, increasing mortality and healthcare costs.
  • Complicating factors include impaired cell function, infections, and inflammation.
  • Current therapies have limited effectiveness.

Purpose of the Study:

  • To review wound healing mechanisms and pathophysiology.
  • To discuss bio-based materials for wound healing.
  • To explore novel strategies for chronic diabetic wounds.

Main Methods:

  • Literature review of wound healing processes.
  • Analysis of bio-based materials' properties and functions.
  • Discussion of emerging therapeutic approaches.

Main Results:

  • Bio-based materials can modulate the wound microenvironment.
  • They inhibit pathogens, reduce inflammation, and promote angiogenesis.
  • These properties enhance cellular processes crucial for healing.

Conclusions:

  • Bio-based materials offer significant potential for advancing wound healing therapies.
  • Further research into bio-based nanomaterials is crucial for chronic wounds.
  • Novel methodologies can convert non-healing wounds into healing ones.
Keywords:
biomaterialsdiabetic woundsnatural productswound healing

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