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A Mini Review of S-Nitrosoglutathione Loaded Nano/Micro-Formulation Strategies
Hui Ming1, Kunpeng Zhang1, Shengbo Ge2
1State Key Laboratory of Heavy Oil Processing, College of Engineering, China University of Petroleum-Beijing at Karamay, Karamay 834000, China.
Abstract:
As a potential therapeutic agent, the clinical application of S-nitrosoglutathione (GSNO) is limited because of its instability. Therefore, different formulations have been developed to protect GSNO from degradation, delivery and the release of GSNO at a physiological concentration in the active position. Due to the high water-solubility and small molecular-size of GSNO, the biggest challenges in the encapsulation step are low encapsulation efficiency and burst release. This review summarizes the different nano/micro-formulation strategies of a GSNO related delivery system to provide references for subsequent researchers interested in GSNO encapsulation.
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