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Nutraceuticals as Potential Therapeutic Modulators in Immunometabolism
Gonzalo Alba1, Hala Dakhaoui1, Consuelo Santa-Maria2
1Department of Medical Biochemistry and Molecular Biology, and Immunology, School of Medicine, University of Seville. Av. Sanchez Pizjuan s/n, 41009 Seville, Spain.
Nutrients
|January 21, 2023
Summary
Nutraceuticals modulate immune cells and their metabolism, offering a therapeutic strategy for chronic inflammatory diseases like obesity and diabetes. These functional foods impact cellular energy pathways, influencing immune responses and overall physiological balance.
Area of Science:
- Immunometabolism
- Nutraceuticals
- Chronic Inflammation
Background:
- Nutraceuticals modulate physiological processes and immune responses in inflammatory conditions.
- Immune cells like antigen-presenting cells (APCs) and T lymphocytes exhibit unique metabolic signatures upon activation.
- Chronic inflammation in obesity and diabetes is linked to altered immune cell metabolism.
Purpose of the Study:
- To review the interplay between metabolism, immune function, and nutraceuticals in chronic inflammatory diseases.
- To highlight the role of nutraceuticals in modulating immune cell metabolism.
- To explore nutritional effects on APC and T cell immunometabolism.
Main Methods:
- Literature review focusing on immunometabolism and nutraceuticals.
- Analysis of cellular energy pathways in immune cell activation.
- Examination of nutraceuticals' impact on metabolic changes in immune cells.
Main Results:
- Nutraceuticals can balance inflammatory responses by modulating immune cell metabolism.
- Specific nutraceuticals (polyphenols, vitamins, fatty acids, sulforaphane) show therapeutic potential.
- Intervention in metabolic pathways via nutraceuticals offers a strategy for managing inflammation.
Conclusions:
- Nutraceuticals represent a promising therapeutic avenue for inflammatory diseases by targeting immune cell metabolism.
- Understanding immunometabolism is key to leveraging nutraceuticals for health and disease prevention.
- Modulating cellular energy metabolism with nutraceuticals can induce significant cellular property changes.
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