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Published on: October 2, 2020
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Water-Soluble Vitamins Status in Patients Undergoing Maintenance Hemodialysis
Małgorzata Kaczkan1, Sylwia Czaja-Stolc1, Małgorzata Szczuko2
1Department of Clinical Nutrition, Medical University of Gdansk, 80-211 Gdańsk, Poland.
Nutrients
|January 21, 2023
Summary
Hemodialysis patients often have deficiencies in water-soluble vitamins like B1, B6, and B12. These vitamin levels correlate with dialysis adequacy and albumin, with diabetes impacting vitamin B1 levels.
Area of Science:
- Nephrology
- Clinical Nutrition
- Biochemistry
Background:
- Water-soluble vitamin deficiencies are common in hemodialysis (HD) patients.
- Routine monitoring of these vitamins is lacking, potentially leading to undiagnosed deficiencies.
- Diabetes mellitus (DM) may further impact vitamin status in HD patients.
Purpose of the Study:
- To compare water-soluble vitamin concentrations in HD patients versus healthy controls.
- To investigate the influence of coexisting diabetes mellitus on vitamin levels in HD patients.
- To explore correlations between vitamin levels and clinical parameters in HD patients.
Main Methods:
- A two-center study involving 142 HD patients and 31 healthy controls.
- Quantification of vitamin concentrations using high-performance liquid chromatography (HPLC).
- Statistical analysis to compare groups and assess correlations.
Main Results:
- HD patients showed significantly lower levels of vitamins B1, B6, and B12 compared to controls (p < 0.001).
- Vitamins B1 and B2 levels correlated negatively with pre-dialysis blood urea nitrogen (BUN).
- Vitamins B3, B12, and C positively correlated with albumin concentration.
- Diabetic HD patients exhibited lower vitamin B1 levels than non-diabetic HD patients.
Conclusions:
- Hemodialysis patients are at risk for deficiencies in several water-soluble vitamins.
- Vitamin levels are associated with dialysis adequacy markers (BUN) and nutritional status (albumin).
- Diabetes mellitus may specifically affect vitamin B1 status in HD patients.
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