Related Experiment Video
Updated: Jun 12, 2026

Purification and Visualization of Influenza A Viral Ribonucleoprotein Complexes
Published on: February 9, 2009
Favipiravir-Tautomeric and Complexation Properties in Solution
Vera Deneva1,2, Sofia Slavova1,3, Alina Kumanova1
1Institute of Electronics, Bulgarian Academy of Sciences, 1784 Sofia, Bulgaria.
Abstract:
The tautomeric properties of favipiravir were investigated experimentally for the first time by using molecular spectroscopy (UV-Vis absorption, fluorescence and NMR), as well as DFT quantum-chemical calculations. According to the obtained results, the enol tautomer is substantially more stable in most of the organic solvents. In the presence of water, a keto form appears to be favored due to the specific solute-solvent interactions. Upon the addition of alkaline-earth-metal ions, deprotonation and complexation occurred simultaneously, giving the formation of 2 : 1 ligand : metal complexes. According to the theoretical simulations, the metal ion is captured between the carbonyl groups as a result of the size-fit effect.
Related Concept Videos
Valence Bond Theory
Inhibitors Of Virion Release
Inhibitors of Virion Maturation and Assembly

