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Different Curcumin-Loaded Delivery Systems for Wound Healing Applications: A Comprehensive Review
Sarah A Sideek1, Hala B El-Nassan2, Ahmed R Fares1
1Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt.
Pharmaceutics
|January 21, 2023
Summary
Curcumin, derived from turmeric, shows promise for wound healing due to its antimicrobial and antioxidant properties. Novel drug delivery systems enhance its effectiveness by improving solubility and bioavailability for better tissue repair.
Area of Science:
- Pharmacology and Material Science
- Focus on natural compounds for therapeutic applications
Background:
- Curcumin, the active compound in turmeric (Curcuma longa L.), possesses significant antibacterial, antifungal, and antioxidant properties beneficial for wound healing.
- Compromised skin integrity triggers natural healing processes, which curcumin can support.
- Limitations of curcumin include poor oral bioavailability, low water solubility, and rapid metabolism, hindering its clinical use.
Purpose of the Study:
- To review recent advancements in curcumin-loaded delivery systems specifically designed for wound healing applications.
- To highlight the advantages of nanoformulations in overcoming curcumin's limitations.
- To explore how these systems enhance curcumin's therapeutic effects on wound repair.
Main Methods:
- Review of recent scientific literature on curcumin delivery systems for wound healing.
- Categorization of delivery systems into traditional forms (hydrogels, films, wafers, sponges) and nanoformulations (nanohydrogels, nanoparticles, nanofibers).
- Analysis of how these formulations improve curcumin's solubility, bioavailability, and release kinetics.
Main Results:
- Various curcumin-loaded systems, including hydrogels, films, wafers, and sponges, have been developed for wound healing.
- Curcumin nanoformulations (nanohydrogels, nanoparticles, nanofibers) demonstrate enhanced solubility, bioavailability, and sustained release.
- These advanced formulations effectively augment curcumin's wound healing capabilities by stimulating different phases of the healing process.
Conclusions:
- Curcumin is a potent agent for wound healing, but its therapeutic potential is constrained by poor physicochemical properties.
- Advanced drug delivery systems, particularly nanoformulations, are crucial for overcoming these limitations.
- Optimized curcumin delivery systems offer a promising strategy to enhance wound repair and restore skin barrier function.
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