Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

8.7K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.7K
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

44
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
44
Regulation of the Cardiovascular System01:27

Regulation of the Cardiovascular System

1.4K
The regulation of the cardiovascular system allows the body to adapt to various demands and maintain homeostasis.
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...
1.4K
Types of RNA01:20

Types of RNA

6.0K
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
6.0K
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

134
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
134
Alternative RNA Splicing02:18

Alternative RNA Splicing

21.6K
Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
21.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bispectral Index-guided Anesthesia and Mortality: Reply.

Anesthesiology·2026
Same author

Low-Cost and Scalable Flexible Infrared Detectors Based on VO<sub>2</sub>(B) Nano-Ink: From Single-Device Sensing to Array Imaging.

ACS applied materials & interfaces·2026
Same author

Non-destructive detection of multiple fatty acids in fuzzy cottonseeds based on near-infrared spectroscopy and chemometrics.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy·2026
Same author

SpatioTemporal Omics Consortium: a global effort for biological discovery across species, space and time.

Nature methods·2026
Same author

HO-1 alleviates lipopolysaccharide-induced acute lung injury in mice by downregulating TFE3 expression and nuclear translocation and suppressing Golgi stress response.

International immunopharmacology·2026
Same author

hsa-miR-375-3p in embryo culture medium exosomes as a preimplantation non-invasive biomarker for predicting live birth after IVF.

Reproductive biomedicine online·2026

Related Experiment Video

Updated: Aug 13, 2025

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
09:53

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

Published on: June 15, 2018

7.5K

Extracellular Non-Coding RNAs in Cardiovascular Diseases.

Zeyidan Jiapaer1,2, Chengyu Li1,2, Xinyu Yang3

  • 1College of Life Science & Technology, Xinjiang University, Urumqi 830046, China.

Pharmaceutics
|January 21, 2023
PubMed
Summary

Extracellular non-coding RNAs (ncRNAs) within vesicles are key to cardiovascular disease (CVD) development. These ncRNAs show promise as diagnostic biomarkers and therapeutic targets for various CVDs.

Keywords:
biomarkerscardiovascular diseasesextracellular RNAsnon-coding RNAstherapeutical targets

More Related Videos

Author Spotlight: Advancing the Analysis of Plasma Extracellular Vesicle Proteome for Cardiovascular Biomarker Studies
05:30

Author Spotlight: Advancing the Analysis of Plasma Extracellular Vesicle Proteome for Cardiovascular Biomarker Studies

Published on: January 31, 2025

562
Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

516

Related Experiment Videos

Last Updated: Aug 13, 2025

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
09:53

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge

Published on: June 15, 2018

7.5K
Author Spotlight: Advancing the Analysis of Plasma Extracellular Vesicle Proteome for Cardiovascular Biomarker Studies
05:30

Author Spotlight: Advancing the Analysis of Plasma Extracellular Vesicle Proteome for Cardiovascular Biomarker Studies

Published on: January 31, 2025

562
Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

516

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cardiology

Background:

  • Cardiovascular diseases (CVDs) are the leading global cause of mortality.
  • Extracellular vesicles (EVs) mediate intercellular communication and are implicated in CVD pathogenesis.
  • Non-coding RNAs (ncRNAs) within EVs are recognized as critical players in these processes.

Purpose of the Study:

  • To review the origin, carriers, and mechanisms of extracellular ncRNAs.
  • To focus on small, circular, and long ncRNAs.
  • To discuss the roles of extracellular ncRNAs in various CVDs and their potential as biomarkers and therapeutics.

Main Methods:

  • Literature review of recent advances in extracellular ncRNA research.
  • Focus on small ncRNAs, circular RNAs, and long ncRNAs.
  • Discussion of pathophysiological roles and clinical applications in CVDs.

Main Results:

  • ncRNAs, including small, circular, and long types, are selectively sorted into EVs and other carriers.
  • Extracellular ncRNAs modulate biological processes in recipient cells.
  • These ncRNAs play significant roles in atherosclerosis, ischemic heart diseases, hypertension, cardiac hypertrophy, and heart failure.

Conclusions:

  • Extracellular ncRNAs are crucial mediators in CVD pathogenesis.
  • They represent promising diagnostic biomarkers and therapeutic targets for cardiovascular diseases.
  • Further research is needed to overcome challenges in their clinical application.