Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Evidence that calcium regulates platelet function.

T C Detwiler, I F Charo, R D Feinman

    Thrombosis and Haemostasis
    |October 31, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Electromyographic Record of Classical Conditioning of Eye Withdrawal in the Crab.

    The Biological bulletin·2018
    Same author

    Obesity, waist-hip ratio and hunter-gatherers.

    BJOG : an international journal of obstetrics and gynaecology·2007
    Same author

    Analysis of corneal inflammation induced by cauterisation in CCR2 and MCP-1 knockout mice.

    The British journal of ophthalmology·2006
    Same author

    To: McAuley KA, Hopkins CM, Smith KJ, McLay RT, Williams SM, Taylor RW, Mann JI (2005) Comparison of high-fat and high-protein diets with a high-carbohydrate diet in insulin-resistant obese women. Diabetologia 48:8-16.

    Diabetologia·2005
    Same author

    The relative contributions of each subset of ocular infiltrated cells in experimental choroidal neovascularisation.

    The British journal of ophthalmology·2004
    Same author

    Ccr2 regulates the level of MCP-1/CCL2 in vitro and at inflammatory sites and controls T cell activation in response to alloantigen.

    Cytokine·2002
    Same journal

    Discontinuation of Oral Anticoagulation After Successful Catheter Ablation for Atrial Fibrillation: Meta-analysis of Randomized Clinical Trials.

    Thrombosis and haemostasis·2026
    Same journal

    Novel/Recurrent Variants in Pakistani Glanzmann Thrombasthenia and Glanzmann-like bleeding diathesis: Insights from NGS Analysis.

    Thrombosis and haemostasis·2026
    Same journal

    Anti-TFPI Single-Domain Antibodies: Novel Rebalancing Therapies for Hemophilia and Other Rare Bleeding Disorders.

    Thrombosis and haemostasis·2026
    Same journal

    The Interaction of Fibrin with Endothelial Cell Receptor N-Cadherin Promotes Fibrin-Dependent Angiogenesis.

    Thrombosis and haemostasis·2026
    Same journal

    Antiphospholipid Antibodies and Atrial Fibrillation: Clinical Implications and the TaPL AF Study Design.

    Thrombosis and haemostasis·2026
    Same journal

    Prasugrel vs. Ticagrelor: Can TUXEDO-2 Settle the Debate?

    Thrombosis and haemostasis·2026
    See all related articles

    Calcium ions are crucial for regulating platelet function, influencing aggregation and secretion. Further research is needed to fully understand calcium

    Area of Science:

    • Biochemistry
    • Hematology
    • Cell Biology

    Background:

    • Calcium ions are widely recognized for their role in cellular processes.
    • Platelet function, including aggregation and secretion, is thought to be regulated by calcium.

    Purpose of the Study:

    • To review the evidence supporting the role of calcium ions in platelet function.
    • To highlight the need for further investigation into platelet calcium pools and fluxes.

    Main Methods:

    • Review of existing evidence, including analogies with other cell types.
    • Analysis of indirect evidence from divalent cation ionophores.
    • Consideration of direct evidence from drugs affecting calcium release.

    Main Results:

    Related Experiment Videos

  • Analogies suggest a general role for calcium in secretion and contraction.
  • Divalent cation ionophores induce platelet aggregation and secretion, similar to other stimuli.
  • Drugs blocking calcium release inhibit platelet activation, with effects reversible by extracellular calcium.

    • Conclusions:

    • The hypothesis of a central role for calcium ions in platelet function is supported by current evidence.
    • Definitive proof requires further studies to elucidate specific calcium pools and their dynamics within platelets.