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Synthesizing Polyurethane Using Isosorbide in Primary Alcohol Form, and Its Biocompatibility Properties.

Suk-Min Hong1, Hyuck-Jin Kwon1, Chil-Won Lee1

  • 1Department of Chemistry, College of Science and Technology, Dankook University, Cheonan 31116, Republic of Korea.

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Summary

Novel bio-based polyurethanes (PUs) derived from modified isosorbide (BHIS) exhibit excellent elasticity and biocompatibility. These advanced PUs show promise for diverse medical applications, highlighting sustainable material innovation.

Keywords:
biocompatibilitybis(2-hydroxyethyl)isosorbideone-shot polymerizationpolycarbonate diolpolyurethane

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Area of Science:

  • Polymer Science
  • Biomaterials Engineering
  • Organic Chemistry

Background:

  • Isosorbide, a renewable resource, is used in polymer synthesis.
  • Modified isosorbide (BHIS) offers enhanced reactivity and favorable structural features for polymerization.
  • Polyurethanes (PUs) are versatile polymers with potential biomedical applications.

Purpose of the Study:

  • To synthesize and characterize novel bio-based polyurethanes (PBH PU series) using BHIS.
  • To investigate the impact of BHIS content on the physical and mechanical properties of the PUs.
  • To evaluate the biocompatibility and potential of these PUs for biomedical applications.

Main Methods:

  • One-shot polymerization of BHIS, polycarbonate diol (PCD), and hexamethylene diisocyanate (HDI) without a catalyst.
  • Characterization using 1H-NMR, FT-IR, DSC, and mechanical testing.
  • Biocompatibility assessment through bone marrow cell adhesion and proliferation assays.

Main Results:

  • The PBH PU series demonstrated exceptional elasticity with high breaking strain (686.55–984.69%) and tensile stress (33.26–63.87 MPa).
  • The synthesized PUs exhibited superb biocompatibility, supporting high adhesion and proliferation of bone marrow cells.
  • Varying BHIS content influenced the physical and mechanical properties of the PBH PU series.

Conclusions:

  • Bio-based PUs synthesized from BHIS possess outstanding mechanical properties and biocompatibility.
  • These novel PUs are suitable for various biomedical applications, offering a sustainable alternative.
  • The study highlights the potential of isosorbide derivatives in developing advanced biomaterials.