Synthesizing Polyurethane Using Isosorbide in Primary Alcohol Form, and Its Biocompatibility Properties

Area of Science:

• Polymer Science
• Biomaterials Engineering
• Organic Chemistry

Background:

• Isosorbide, a renewable resource, is used in polymer synthesis.
• Modified isosorbide (BHIS) offers enhanced reactivity and favorable structural features for polymerization.
• Polyurethanes (PUs) are versatile polymers with potential biomedical applications.

Purpose of the Study:

• To synthesize and characterize novel bio-based polyurethanes (PBH PU series) using BHIS.
• To investigate the impact of BHIS content on the physical and mechanical properties of the PUs.
• To evaluate the biocompatibility and potential of these PUs for biomedical applications.

Main Methods:

• One-shot polymerization of BHIS, polycarbonate diol (PCD), and hexamethylene diisocyanate (HDI) without a catalyst.
• Characterization using 1H-NMR, FT-IR, DSC, and mechanical testing.
• Biocompatibility assessment through bone marrow cell adhesion and proliferation assays.

Main Results:

• The PBH PU series demonstrated exceptional elasticity with high breaking strain (686.55–984.69%) and tensile stress (33.26–63.87 MPa).
• The synthesized PUs exhibited superb biocompatibility, supporting high adhesion and proliferation of bone marrow cells.
• Varying BHIS content influenced the physical and mechanical properties of the PBH PU series.

Conclusions:

• Bio-based PUs synthesized from BHIS possess outstanding mechanical properties and biocompatibility.
• These novel PUs are suitable for various biomedical applications, offering a sustainable alternative.
• The study highlights the potential of isosorbide derivatives in developing advanced biomaterials.