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Basophilic leukaemia in a dog.
E A Mahaffey1, T P Brown, J R Duncan
1Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens 30602.
Journal of Comparative Pathology
|July 1, 1987
Summary
Canine leukemia was identified in an 11-year-old female dog. The neoplastic cells were classified as basophils based on their unique characteristics and negative cytochemical stains.
Area of Science:
- Veterinary Medicine
- Hematology
- Oncology
Background:
- Leukemia is a cancer of blood-forming tissues.
- Accurate classification of leukemia subtypes is crucial for diagnosis and treatment.
Purpose of the Study:
- To characterize and classify a case of leukemia in a dog.
- To identify the specific cell type involved in the canine leukemia.
Main Methods:
- Analysis of peripheral blood and bone marrow samples.
- Morphological examination of neoplastic cells.
- Cytochemical staining for peroxidase and naphthol AS-D chloracetate esterase.
- Ultrastructural examination using electron microscopy.
Main Results:
- Cells exhibited lobulated nuclei and numerous metachromatic cytoplasmic granules.
- Cytochemical stains for peroxidase and esterase were negative.
- Ultrastructural analysis revealed finely granular cytoplasmic granules without specific organized structures.
- Neoplastic cells were identified as basophils.
Conclusions:
- The canine leukemia case was characterized by neoplastic basophils.
- Morphological and ultrastructural findings, along with negative cytochemical stains, supported the classification.
- This case highlights the importance of comprehensive diagnostic methods in veterinary hematopathology.