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Evaluating Johnson and Johnson COVID-19 Vaccination Outcomes in a Low-Income Hispanic Population

Christopher Lamb1, Christopher Owens2, Wendy Gamboa2

  • 1Weatherhead School of Management, Case Western Reserve University, Cleveland, OH 44106, USA.

Vaccines
|January 21, 2023
PubMed

Insights

This study assessed the Johnson & Johnson COVID-19 vaccine

Area of Science:

  • Immunology
  • Vaccinology
  • Public Health

Background:

  • Pilot study conducted at a low-income clinic.
  • Focus on assessing humoral immune response to Johnson & Johnson COVID-19 vaccine (Ad26.COV2.S).
  • Aimed to evaluate COVID-19 health status in a Hispanic patient population post-vaccination.

Purpose of the Study:

  • To assess the humoral immune response to the Johnson & Johnson COVID-19 vaccine.
  • To understand methods for evaluating COVID-19 health status in a specific demographic.
  • To explore the utility of rapid antibody tests for monitoring vaccine effectiveness.

Main Methods:

  • Utilized the Clungene® SARS-CoV-2 IgG/IgM Rapid Test Cassette.
  • Detected antibodies targeting the receptor-binding domain (RBD) of the spike protein.
  • Antibodies against the spike protein served as a measure of humoral response.

Main Results:

  • Confirmed antibody waning over time, consistent with reported vaccine efficacy.
  • Identified a statistically significant relationship between immune response and demographic/health variables.
  • Demonstrated the potential for antibody testing to monitor vaccine effectiveness.

Conclusions:

  • COVID-19 negative patients can be monitored for vaccine success and durability.
  • Low-cost antibody lateral flow devices can aid physicians in assessing patient COVID-19 health status.
  • Further research is recommended to confirm the clinical utility of this monitoring approach.
Abstract

Keywords:
COVID-19 Hispanic impactCOVID-19 antibodiesCOVID-19 humoral responseCOVID-19 low-income populationClungene®Johnson & Johnson COVID-19 vaccine

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