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Hyperplastic acral keratoses--association with invasive squamous cell carcinoma
1Department of Pathology, University of Utah Medical Center, Salt Lake City 84132.
The Journal of Dermatologic Surgery and Oncology
|November 1, 1987
Summary
Sun-damaged skin can develop hyperplastic epidermal lesions that may contain invasive squamous cell carcinoma. Physicians may misdiagnose these as benign due to bland histology, necessitating clinical correlation and follow-up.
Area of Science:
- Dermatopathology
- Oncology
Background:
- Sun-damaged skin frequently exhibits epidermal changes.
- Hyperplastic epidermal lesions are common in chronically sun-exposed areas.
Purpose of the Study:
- To characterize hyperplastic epidermal lesions in sun-damaged skin.
- To identify the presence of squamous cell carcinoma within these lesions.
- To highlight potential diagnostic challenges in small biopsies.
Main Methods:
- Histopathological examination of epidermal lesions from sun-damaged skin.
- Clinical correlation of histological findings.
- Review of cases with foci of invasive squamous cell carcinoma.
Main Results:
- Hyperplastic epidermal lesions were observed on the hands, wrists, and forearms.
- Some lesions contained foci of invasive squamous cell carcinoma.
- Atypia in these lesions was often focal or absent, mimicking benign conditions.
Conclusions:
- Hyperplastic epidermal lesions in sun-damaged skin can harbor invasive squamous cell carcinoma.
- The bland histology may lead to misdiagnosis of small or superficial biopsies as benign.
- Clinical correlation and diligent follow-up are crucial for detecting residual or precursor carcinoma.