Pullulan in pharmaceutical and cosmeceutical formulations: A review

Area of Science:

• Biochemistry
• Polymer Science
• Materials Science

Background:

• Pullulan is a natural, edible, and biodegradable α-glucan polysaccharide.
• Its structure features α-(1→4) and α-(1→6) glycosidic linkages, conferring unique properties.
• These properties make pullulan suitable for various advanced applications.

Purpose of the Study:

• To review the extensive applications of pullulan in the pharmaceutical industry.
• To highlight the utility of pullulan in cosmeceutical formulations.
• To underscore pullulan's potential as a carrier for active ingredients.

Main Methods:

• Literature review of scientific publications and patents.
• Analysis of pullulan's chemical structure and properties.
• Categorization of applications based on industry (pharmaceutical and cosmeceutical).

Main Results:

• Pullulan serves as an effective drug carrier in diverse pharmaceutical dosage forms, including ocular, topical, and oral formulations.
• Its biocompatibility and biodegradability are key advantages in drug delivery systems.
• Pullulan facilitates site-specific delivery of active ingredients in cosmeceuticals like creams, lotions, and sunscreens.

Conclusions:

• Pullulan's unique structure and properties enable its broad use in pharmaceutical and cosmeceutical sectors.
• It is a valuable excipient for drug formulation and active ingredient delivery.
• Further research can explore novel applications leveraging pullulan's characteristics.