Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Olfactory Receptors: Location and Structure01:03

Olfactory Receptors: Location and Structure

9.4K
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
9.4K
Physiology of Smell and Olfactory Pathway01:20

Physiology of Smell and Olfactory Pathway

9.0K
Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
9.0K
Olfaction01:25

Olfaction

44.8K
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
44.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A multifeature machine learning and resting-state EEG study reveals differences in beta oscillation in late-life depression with or without mild cognitive impairment.

BMC psychiatry·2026
Same author

Olfactory radiomics signatures link pTau217 to cognitive impairment in probable Alzheimer's disease: a multi-cohort machine learning study.

Alzheimer's research & therapy·2026
Same author

Sex-Specific regional brain activity and cognitive function in mild cognitive impairment: An rs-fMRI study.

Translational psychiatry·2026
Same author

Triple Long-Range Charge-Transfer Channels Enable Efficient LRCT/SRCT Hybridization in Narrowband Deep-Blue TADF Emission.

Angewandte Chemie (International ed. in English)·2026
Same author

Altered temporal dynamics of intrinsic brain activity in mild cognitive impairment with olfactory dysfunction.

Journal of Alzheimer's disease : JAD·2026
Same author

Differential effects of PSEN1 mutations (p.P117L with ataxia and p.P264L without ataxia) in early-onset Alzheimer's disease.

Journal of Alzheimer's disease : JAD·2026

Related Experiment Video

Updated: Aug 13, 2025

Author Spotlight: Assessing the Olfactory Effects of Airborne Pollutants — Buried Food and Social Odor Tests
04:00

Author Spotlight: Assessing the Olfactory Effects of Airborne Pollutants — Buried Food and Social Odor Tests

Published on: September 13, 2024

921

Odor deprivation influences human olfactory function.

Ben Chen1, Anabel Stein2, Falk-Tony Olesch2

  • 1Smell & Taste Clinic, Department of Otorhinolaryngology, Dresden, TU Germany; Center for Geriatric Neuroscience, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, Guangdong Province, China.

Physiology & Behavior
|January 21, 2023
PubMed
Summary
This summary is machine-generated.

Odor deprivation using a nasal device impairs olfactory function, particularly odor thresholds. This study suggests olfactory plasticity and potential therapeutic uses for smell disorders.

Keywords:
HyposmiaMaskNoseOdor deprivationOlfactionWell-being

More Related Videos

Author Spotlight: Exploring Olfactory Influences on Corticospinal Excitability - Insights and Innovations in Neurological Research
06:13

Author Spotlight: Exploring Olfactory Influences on Corticospinal Excitability - Insights and Innovations in Neurological Research

Published on: January 19, 2024

1.1K
A Free-breathing fMRI Method to Study Human Olfactory Function
10:42

A Free-breathing fMRI Method to Study Human Olfactory Function

Published on: July 30, 2017

9.7K

Related Experiment Videos

Last Updated: Aug 13, 2025

Author Spotlight: Assessing the Olfactory Effects of Airborne Pollutants — Buried Food and Social Odor Tests
04:00

Author Spotlight: Assessing the Olfactory Effects of Airborne Pollutants — Buried Food and Social Odor Tests

Published on: September 13, 2024

921
Author Spotlight: Exploring Olfactory Influences on Corticospinal Excitability - Insights and Innovations in Neurological Research
06:13

Author Spotlight: Exploring Olfactory Influences on Corticospinal Excitability - Insights and Innovations in Neurological Research

Published on: January 19, 2024

1.1K
A Free-breathing fMRI Method to Study Human Olfactory Function
10:42

A Free-breathing fMRI Method to Study Human Olfactory Function

Published on: July 30, 2017

9.7K

Area of Science:

  • Neuroscience
  • Sensory Science
  • Otolaryngology

Background:

  • Odor deprivation causes changes in the olfactory system, but human effects are under-explored.
  • Understanding olfactory system plasticity is crucial for sensory science.

Purpose of the Study:

  • To investigate the impact of different odor deprivation methods on human olfactory function.
  • To assess olfactory function, nasal patency, and well-being after a 14-day intervention.

Main Methods:

  • Randomized controlled study with 61 healthy participants.
  • Three groups: nasal device, mask, and control.
  • Olfactory assessments, nasal patency, and well-being measured before and after the intervention.

Main Results:

  • The nasal device group showed significantly reduced TDI scores, especially odor thresholds.
  • The mask group had a slight increase in odor identification compared to controls.
  • Improved well-being correlated with better odor identification and TDI scores.

Conclusions:

  • Intranasal air diversion devices cause olfactory impairment, particularly affecting odor thresholds.
  • The olfactory system exhibits exposure-driven plasticity, offering a model for studying hyposmia.
  • This method may benefit patients with parosmia by reducing unpleasant smell sensations.