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Good and evil, more reasons to study UPR
1Division of CKD Pathophysiology, The University of Tokyo, Graduate School of Medicine, Tokyo, Japan.
Kidney International
|January 21, 2023
Summary
The unfolded protein response (UPR) pathway protects kidneys but is hard to control in disease. This review explores strategies to sustain this kidney-protective UPR pathway for better treatment.
Area of Science:
- Cellular Biology
- Nephrology
- Molecular Medicine
Background:
- The endoplasmic reticulum's unfolded protein response (UPR) pathway is crucial for maintaining cellular homeostasis.
- Dysregulation of the UPR pathway is implicated in kidney disease pathogenesis, contributing to proteinuria, inflammation, and fibrosis.
- While the UPR shows therapeutic potential, controlling its adaptive state for effective disease treatment remains challenging.
Purpose of the Study:
- To provide insights into strategies for sustaining the kidney-protective UPR pathway.
- To explore the therapeutic potential of targeting the UPR in kidney disease.
- To address the difficulties in controlling adaptive UPR status for disease management.
Main Methods:
- Literature review and synthesis of existing research on the UPR pathway in kidney disease.
- Analysis of the mechanisms underlying UPR dysregulation in kidney pathologies.
- Discussion of potential therapeutic approaches targeting the UPR.
Main Results:
- Accumulating evidence supports the beneficial role of the UPR pathway in various diseases, including kidney disease.
- Dysfunctional UPR contributes to key pathological features of kidney disease.
- Controlling adaptive UPR remains a significant hurdle in therapeutic development.
Conclusions:
- Sustaining the kidney-protective UPR pathway is a promising therapeutic strategy.
- Further research is needed to develop methods for precise control of the UPR.
- Understanding UPR regulation is key to advancing kidney disease treatment.
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