Related Experiment Video

Updated: Aug 13, 2025

Continuous Theta Burst Stimulation of the Posterior Medial Frontal Cortex to Experimentally Reduce Ideological Threat Responses
06:42

Continuous Theta Burst Stimulation of the Posterior Medial Frontal Cortex to Experimentally Reduce Ideological Threat Responses

Published on: September 28, 2018

11.7K

Good and evil, more reasons to study UPR

Reiko Inagi1, Sho Hasegawa1

  • 1Division of CKD Pathophysiology, The University of Tokyo, Graduate School of Medicine, Tokyo, Japan.

Kidney International
|January 21, 2023
PubMed

Insights

The unfolded protein response (UPR) pathway protects kidneys but is hard to control in disease. This review explores strategies to sustain this kidney-protective UPR pathway for better treatment.

Area of Science:

  • Cellular Biology
  • Nephrology
  • Molecular Medicine

Background:

  • The endoplasmic reticulum's unfolded protein response (UPR) pathway is crucial for maintaining cellular homeostasis.
  • Dysregulation of the UPR pathway is implicated in kidney disease pathogenesis, contributing to proteinuria, inflammation, and fibrosis.
  • While the UPR shows therapeutic potential, controlling its adaptive state for effective disease treatment remains challenging.

Purpose of the Study:

  • To provide insights into strategies for sustaining the kidney-protective UPR pathway.
  • To explore the therapeutic potential of targeting the UPR in kidney disease.
  • To address the difficulties in controlling adaptive UPR status for disease management.

Main Methods:

  • Literature review and synthesis of existing research on the UPR pathway in kidney disease.
  • Analysis of the mechanisms underlying UPR dysregulation in kidney pathologies.
  • Discussion of potential therapeutic approaches targeting the UPR.

Main Results:

  • Accumulating evidence supports the beneficial role of the UPR pathway in various diseases, including kidney disease.
  • Dysfunctional UPR contributes to key pathological features of kidney disease.
  • Controlling adaptive UPR remains a significant hurdle in therapeutic development.

Conclusions:

  • Sustaining the kidney-protective UPR pathway is a promising therapeutic strategy.
  • Further research is needed to develop methods for precise control of the UPR.
  • Understanding UPR regulation is key to advancing kidney disease treatment.

More Related Videos

The Resident-intruder Paradigm: A Standardized Test for Aggression, Violence and Social Stress09:12

The Resident-intruder Paradigm: A Standardized Test for Aggression, Violence and Social Stress

Published on: July 4, 2013

71.1K
Investigating Pain-Related Avoidance Behavior using a Robotic Arm-Reaching Paradigm09:00

Investigating Pain-Related Avoidance Behavior using a Robotic Arm-Reaching Paradigm

Published on: October 3, 2020

4.0K

Related Concept Videos

Fundamental Attribution Error01:14

Fundamental Attribution Error

According to some social psychologists, people tend to overemphasize internal factors as explanations—or attributions—for the behavior of other people. They tend to assume that the behavior of another person is a trait of that person, and to underestimate the power of the situation on the behavior of others. They tend to fail to recognize when the behavior of another is due to situational variables, and thus to the person’s state. This erroneous assumption is...
12.9K
Ethics in Research01:56

Ethics in Research

Today, scientists agree that good research is ethical in nature and is guided by a basic respect for human dignity and safety. However, this has not always been the case. Modern researchers must demonstrate that the research they perform is ethically sound.
23.1K
Ethical Issues01:27

Ethical Issues

Nurses are essential in patient care, upholding the ethical principles of their profession and effectively navigating ethical dilemmas. Neglecting ethical issues can lead to inadequate patient care, compromised therapeutic relationships, and moral distress among healthcare workers.
Ethical Concerns in Healthcare:
1.1K
Criticisms of the Evolutionary Perspective01:23

Criticisms of the Evolutionary Perspective

In a study where individuals posing as strangers offered compliments and proposed casual sex to students, the responses differed significantly based on gender. Not a single woman accepted the proposal, while 70% of the men agreed. This outcome provides a useful scenario to explore through the lens of evolutionary psychology and social learning theory, highlighting the diverse perspectives on human sexual behaviors.
Evolutionary psychology provides one explanation for these findings, suggesting...
142
Humanistic Psychology01:24

Humanistic Psychology

Humanistic psychology emerged in the mid-20th century as a response to the deterministic and pessimistic nature of behaviorism and psychoanalysis. While behaviorism focused on observable behaviors influenced by the environment and psychoanalysis delved into unconscious motivations, both theories suggested that human actions lacked free will. In contrast, humanistic psychology offers a perspective that emphasizes the innate potential for goodness and growth within every individual.
This approach...
1.2K
Kohlberg's Theory of Moral Development01:19

Kohlberg's Theory of Moral Development

Kohlberg's theory of moral development uses the Heinz dilemma — a thought experiment in which a man, Heinz, must decide whether to steal an unaffordable drug to save his dying wife — to illustrate the evolution of moral reasoning. This framework, divided into three levels with two stages, highlights how individuals' understanding of right and wrong becomes increasingly complex.
Pre-Conventional Level
At the pre-conventional level, morality is primarily driven by personal...
110