Related Experiment Video
Updated: Aug 13, 2025
Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production
Published on: March 2, 2014
[Cytomegalovirus reactivation in patients with immune-mediated gastritis]
Diana Paredes-Ruiz1, Flora López-López2, Juan Antonio Núñez-Sobrino2
1Servicio de Medicina Interna, Hospital Universitario 12 de Octubre, Madrid, España.
Introduction:
Reactivation of cytomegalovirus can complicate the evolution of patients with gastritis induced by immune checkpoint inhibitors.
Methods:
The experience in our center is described and a review of the literature is performed.
Results:
A case of severe gastritis induced by treatment with a programmed cell death receptor-1 (anti-PD1) inhibitor, associated with reactivation of cytomegalovirus (CMV) is described. In the systematic review, we identified 5 cases of immune-related gastritis associated with CMV reactivation. Ganciclovir treatment contributed to clinical improvement in most patients.
Conclusion:
The early identification of a CMV infection in patients with severe or refractory immune-related gastritis will allow the initiation of targeted treatment, and may avoid increasing immunosuppressive therapy.
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